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MGP004372

UniProt Annotations

Entry Information

Gene Name	sialidase 3 (membrane sialidase)
Protein Entry	NEUR3_HUMAN
UniProt ID	Q9UQ49
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UQ49-1; Sequence=Displayed; Name=2; IsoId=Q9UQ49-2; Sequence=VSP_054145;
Biophysicochemical Properties	pH dependence: Optimum pH is 3.8.;
Catalytic Activity	Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. {ECO:0000269\|PubMed:10861246, ECO:0000269\|PubMed:20511247}.
Function	Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. {ECO:0000269\|PubMed:10861246, ECO:0000269\|PubMed:20511247}.
Sequence Caution	Sequence=CAB96131.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity	Belongs to the glycosyl hydrolase 33 family. {ECO:0000305}.
Similarity	Contains 3 BNR repeats. {ECO:0000305}.
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:10861246}; Peripheral membrane protein {ECO:0000269\|PubMed:10861246}.
Tissue Specificity	Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung. {ECO:0000269\|PubMed:10861246}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/NEU3ID44505ch11q13.html";