MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004951

UniProt Annotations

Entry Information
Gene NameLSM1, U6 small nuclear RNA associated
Protein EntryLSM1_HUMAN
UniProt IDO15116
SpeciesHuman
Comments
Comment typeDescription
FunctionPlays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal U-tract of U6 snRNA. {ECO:0000269|PubMed:18172165}.
InteractionQ9Y333:LSM2; NbExp=3; IntAct=EBI-347619, EBI-347416; P62310:LSM3; NbExp=3; IntAct=EBI-347619, EBI-348239;
SimilarityBelongs to the snRNP Sm proteins family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000305}.
SubunitInteracts with SLBP. Interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a doughnut shape. {ECO:0000269|PubMed:18172165}.
Tissue SpecificityHas elevated expression in pancreatic cancer and in several cancer-derived cell lines.
  logo