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MGP005196

UniProt Annotations

Entry Information
Gene Namenegative elongation factor complex member C/D
Protein EntryNELFD_HUMAN
UniProt IDQ8IXH7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing, Alternative initiation; Named isoforms=3; Name=NELF-C; IsoId=Q8IXH7-1; Sequence=Displayed; Name=3; IsoId=Q8IXH7-3; Sequence=VSP_008950, VSP_008951; Note=No experimental confirmation available.; Name=NELF-D; IsoId=Q8IXH7-4; Sequence=VSP_018769; Note=Produced by alternative initiation at Met-10 of isoform NELF-C.;
FunctionEssential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12612062}.
InteractionP10398:ARAF; NbExp=5; IntAct=EBI-536725, EBI-365961; Q9H3P2:NELFA; NbExp=3; IntAct=EBI-6109710, EBI-5461341;
Sequence CautionSequence=AAF29094.1; Type=Frameshift; Positions=462, 464; Evidence={ECO:0000305}; Sequence=BAA91618.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14519.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB64339.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the NELF-D family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000305}.
SubunitThe NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE. Interacts with ARAF1. {ECO:0000269|PubMed:11952167, ECO:0000269|PubMed:12612062}.
Tissue SpecificityWidely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas. {ECO:0000269|PubMed:11030415, ECO:0000269|PubMed:12612062}.
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