MGP Database

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MGP005219

UniProt Annotations

Entry Information
Gene Namesplicing factor 3b, subunit 6, 14kDa
Protein EntrySF3B6_HUMAN
UniProt IDQ9Y3B4
SpeciesHuman
Comments
Comment typeDescription
FunctionNecessary for the splicing of pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively. {ECO:0000269|PubMed:16432215}.
SimilarityBelongs to the SF3B6 family. {ECO:0000305}.
SimilarityContains 1 RRM (RNA recognition motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00176}.
Subcellular LocationNucleus {ECO:0000305}.
SubunitComponent of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A/SF3B14B, and DDX42/SF3B125. Interacts with SF3B1. Component of the U11/U12 snRNPs that are part of the U12- type spliceosome. {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:12738865, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:16432215, ECO:0000269|PubMed:21062891}.
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