MGP Database

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MGP005340

Ontology/Pathway Information

Entrez Gene ID54894
Gene Namering finger protein 43
Gene Symbol RNF43
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005789 IEA:UniProtKB-SubCellCendoplasmic reticulum membrane
GO:0005887 IDA:UniProtKBCintegral component of plasma membrane
GO:0005635 IEA:UniProtKB-SubCellCnuclear envelope
GO:0005109 IPI:UniProtKBFfrizzled binding
GO:0016874 IEA:UniProtKB-KWFligase activity
GO:0004842 IDA:UniProtKBFubiquitin-protein transferase activity
GO:0008270 IEA:InterProFzinc ion binding
GO:0030178 IMP:UniProtKBPnegative regulation of Wnt signaling pathway
GO:0016567 IDA:UniProtKBPprotein ubiquitination
GO:0042787 IDA:UniProtKBPprotein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0072089 ISS:UniProtKBPstem cell proliferation
GO:0038018 IDA:UniProtKBPWnt receptor catabolic process
GO:0016055 IEA:UniProtKB-KWPWnt signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_264580regulation of FZD by ubiquitination
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264596TCF dependent signaling in response to WNT
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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