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MGP005340

UniProt Annotations

Entry Information
Gene Namering finger protein 43
Protein EntryRNF43_HUMAN
UniProt IDQ68DV7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q68DV7-1; Sequence=Displayed; Name=2; IsoId=Q68DV7-2; Sequence=VSP_037339; Note=No experimental confirmation available.; Name=3; IsoId=Q68DV7-3; Sequence=VSP_037338; Note=No experimental confirmation available.; Name=4; IsoId=Q68DV7-4; Sequence=VSP_037340; Note=No experimental confirmation available.;
FunctionE3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. {ECO:0000269|PubMed:18313049, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22895187}.
InteractionQ9ULX6:AKAP8L; NbExp=2; IntAct=EBI-1647060, EBI-357530; P0CG47:UBB; NbExp=2; IntAct=EBI-1647060, EBI-413034; P62837:UBE2D2; NbExp=2; IntAct=EBI-1647060, EBI-347677; P61077:UBE2D3; NbExp=2; IntAct=EBI-1647060, EBI-348268;
MiscellaneousActs as a cytotoxic T-lymphocyte tumor antigen, suggesting that it may be used as a target for cancer immunotherapy. {ECO:0000305|PubMed:15623641}.
PathwayProtein modification; protein ubiquitination.
PtmAutoubiquitinated. {ECO:0000269|PubMed:18313049}.
Sequence CautionSequence=BAH12871.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the ZNRF3 family. {ECO:0000305}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
Subcellular LocationCell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted. {ECO:0000269|PubMed:15492824}.
SubunitInteracts with AKAP8L, NONO and SFPQ. Interacts with FZD5. Identified in a complex composed of RNF43, LGR5 and RSPO1. {ECO:0000269|PubMed:18313049, ECO:0000269|PubMed:18655028, ECO:0000269|PubMed:22895187, ECO:0000269|PubMed:23756651}.
Tissue SpecificityExpressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines. {ECO:0000269|PubMed:15492824, ECO:0000269|PubMed:18313049}.
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