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MGP005717

UniProt Annotations

Entry Information
Gene Namephosphopantothenoylcysteine decarboxylase
Protein EntryCOAC_HUMAN
UniProt IDQ96CD2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96CD2-1; Sequence=Displayed; Name=2; IsoId=Q96CD2-2; Sequence=VSP_044802; Note=The Met-1 codon is associated with a polymorphism (dbSNP:rs2304899) that replaces the initiation ATG codon by an ATA codon.;
Catalytic ActivityN-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO(2).
CofactorName=FMN; Xref=ChEBI:CHEBI:58210; Note=Binds 1 FMN per subunit.;
FunctionNecessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'- phosphopantotheine. {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:15581364}.
PathwayCofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.
SimilarityBelongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily. {ECO:0000305}.
SubunitHomotrimer. {ECO:0000305}.
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