MGP Database

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MGP005844

Ontology/Pathway Information

Entrez Gene ID79017
Gene Namegamma-glutamylcyclotransferase
Gene Symbol GGCT
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IDA:UniProtKBCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0003839 IDA:UniProtKBFgamma-glutamylcyclotransferase activity
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0006750 TAS:ReactomePglutathione biosynthetic process
GO:1901687 TAS:ReactomePglutathione derivative biosynthetic process
GO:0001836 IMP:UniProtKBPrelease of cytochrome c from mitochondria
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13433Biological oxidations
REACT_268587Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
REACT_268321Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
REACT_268129Defective GGT1 causes Glutathionuria (GLUTH)
REACT_267887Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
REACT_268063Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
REACT_268256Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
REACT_267818Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
REACT_268027Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
REACT_268058Defective UGT1A1 causes hyperbilirubinemia
REACT_268618Defective UGT1A4 causes hyperbilirubinemia
REACT_116125Disease
REACT_6926Glutathione conjugation
REACT_6960Glutathione synthesis and recycling
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_6959Phase II conjugation
SMP Pathway Links
SMP IDDescription
SMP005005-oxoprolinase deficiency
SMP001435-Oxoprolinuria
SMP00183Gamma-Glutamyltransferase Deficiency
SMP00501Gamma-glutamyl-transpeptidase deficiency
SMP00015Glutathione Metabolism
SMP00337Glutathione Synthetase Deficiency
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