MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP005844

UniProt Annotations

Entry Information
Gene Namegamma-glutamylcyclotransferase
Protein EntryGGCT_HUMAN
UniProt IDO75223
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=O75223-1; Sequence=Displayed; Name=2; IsoId=O75223-2; Sequence=VSP_035599, VSP_035600; Note=No experimental confirmation available.; Name=3; IsoId=O75223-3; Sequence=VSP_046463; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=4; IsoId=O75223-4; Sequence=VSP_046464; Note=No experimental confirmation available. Gene prediction based on EST data.;
Biophysicochemical PropertiesKinetic parameters: KM=2.0 mM for gamma-glutamyl-L-alanine; Vmax=50.3 umol/min/mg enzyme;
Catalytic Activity(Gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.
FunctionCatalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. {ECO:0000269|PubMed:16765912, ECO:0000269|PubMed:18515354}.
InductionBy geranylgeraniol. {ECO:0000269|PubMed:16765912}.
SimilarityBelongs to the gamma-glutamylcyclotransferase family. {ECO:0000305}.
SubunitHomodimer. {ECO:0000305|PubMed:17932939, ECO:0000305|PubMed:18515354}.
  logo