MGP Database

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MGP006069

Ontology/Pathway Information

Entrez Gene ID83439
Gene Nametranscription factor 7-like 1 (T-cell specific, HMG-box)
Gene Symbol TCF7L1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005634 NAS:UniProtKBCnucleus
GO:0005667 IBA:GO_CentralCtranscription factor complex
GO:0008013 IBA:GO_CentralFbeta-catenin binding
GO:0003682 IBA:GO_CentralFchromatin binding
GO:0003677 NAS:UniProtKBFDNA binding
GO:0043565 IBA:GO_CentralFsequence-specific DNA binding
GO:0003700 NAS:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0044212 IBA:GO_CentralFtranscription regulatory region DNA binding
GO:0008595 IEA:EnsemblPanterior/posterior axis specification, embryo
GO:0048319 IEA:EnsemblPaxial mesoderm morphogenesis
GO:0007420 IBA:GO_CentralPbrain development
GO:0060070 IBA:GO_CentralPcanonical Wnt signaling pathway
GO:0006325 NAS:UniProtKBPchromatin organization
GO:0048699 IBA:GO_CentralPgeneration of neurons
GO:0045892 IEA:EnsemblPnegative regulation of transcription, DNA-templated
GO:0046022 IEA:EnsemblPpositive regulation of transcription from RNA polymerase II promoter during mitosis
GO:2000036 IEA:EnsemblPregulation of stem cell maintenance
GO:0006355 NAS:UniProtKBPregulation of transcription, DNA-templated
GO:0006357 IBA:GO_CentralPregulation of transcription from RNA polymerase II promoter
GO:0030111 NAS:UniProtKBPregulation of Wnt signaling pathway
GO:0043588 IEA:EnsemblPskin development
GO:0035019 IEA:EnsemblPsomatic stem cell maintenance
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264511AMER1 mutants destabilize the destruction complex
REACT_263859APC truncation mutants are not K63 polyubiquitinated
REACT_263992APC truncation mutants have impaired AXIN binding
REACT_264030AXIN missense mutants destabilize the destruction complex
REACT_264496AXIN mutants destabilize the destruction complex, activating WNT signaling
REACT_264224beta-catenin independent WNT signaling
REACT_264532binding of TCF/LEF:CTNNB1 to target gene promoters
REACT_263982Ca2+ pathway
REACT_264178deactivation of the beta-catenin transactivating complex
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_263937deletions in the AMER1 gene destabilize the destruction complex
REACT_264286deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
REACT_116125Disease
REACT_264242formation of the beta-catenin:TCF transactivating complex
REACT_264092misspliced GSK3beta mutants stabilize beta-catenin
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_263863phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REACT_264567repression of WNT target genes
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_264581S33 mutants of beta-catenin aren't phosphorylated
REACT_264636S37 mutants of beta-catenin aren't phosphorylated
REACT_264295S45 mutants of beta-catenin aren't phosphorylated
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264127T41 mutants of beta-catenin aren't phosphorylated
REACT_264499TCF7L2 mutants don't bind CTBP
REACT_264596TCF dependent signaling in response to WNT
REACT_264621truncated APC mutants destabilize the destruction complex
REACT_263893truncations of AMER1 destabilize the destruction complex
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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