MGP Database

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MGP006069

UniProt Annotations

Entry Information
Gene Nametranscription factor 7-like 1 (T-cell specific, HMG-box)
Protein EntryTF7L1_HUMAN
UniProt IDQ9HCS4
SpeciesHuman
Comments
Comment typeDescription
DomainThe putative Groucho interaction domain between the N- terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1. {ECO:0000250}.
FunctionParticipates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. {ECO:0000250}.
SimilarityBelongs to the TCF/LEF family. {ECO:0000305}.
SimilarityContains 1 HMG box DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00267}.
Subcellular LocationNucleus.
SubunitBinds the armadillo repeat of CTNNB1 and forms a stable complex. {ECO:0000250}.
Tissue SpecificityDetected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium. {ECO:0000269|PubMed:9916915}.
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