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MGP006076

UniProt Annotations

Entry Information
Gene Nameuridine-cytidine kinase 1
Protein EntryUCK1_HUMAN
UniProt IDQ9HA47
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9HA47-1; Sequence=Displayed; Name=2; IsoId=Q9HA47-2; Sequence=VSP_041269; Note=Ref.8 (AAH15547) sequence is in conflict in position: 180:A->T. {ECO:0000305}; Name=3; IsoId=Q9HA47-3; Sequence=VSP_045174; Name=4; IsoId=Q9HA47-4; Sequence=VSP_056748;
Catalytic ActivityATP + cytidine = ADP + CMP.
Catalytic ActivityATP + uridine = ADP + UMP.
FunctionPhosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine.
PathwayPyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.
PathwayPyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.
SimilarityBelongs to the uridine kinase family. {ECO:0000305}.
Tissue SpecificityUbiquitous.
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