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MGP006535

Record overview

MGPD IDMGP006535
Gene ID135250
SpeciesHomo sapiens (Human)
Gene Nameretinoic acid early transcript 1E
Gene Symbol RAET1E
SynonymsRL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7;
Alternate namesNKG2D ligand 4; RAE-1-like transcript 4; lymphocyte effector toxicity activation ligand;
Chromosome6
Map Location6q25.1
SummaryThis gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for RAET1E

Proteins

NKG2D ligand 4 isoform 1 precursor
Refseq ID:NP_631904
Protein GI:21040249
UniProt ID:Q8TD07
mRNA ID:NM_139165
Length:263
RefSeq Status:
MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRD
LRMLLCDIKPQIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHW
EAMPEPTVSPVNASDIHWSSSSLPDRWIILGAFILLVLMGIVLICVWWQNGEWQAGLWPLRTS
 
sig_peptide: 1..30
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q8TD07.1)
calculated_mol_wt: 3339
peptide sequence: 
MRRISLTSSPVRLLLFLLLLLIALEIMVGG

mat_peptide: 31..263
product: NKG2D ligand 4
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q8TD07.1)
calculated_mol_wt: 26801
peptide sequence: 
HSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREA
ERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDRWIIL
GAFILLVLMGIVLICVWWQNGEWQAGLWPLRTS
 
NKG2D ligand 4 isoform 2 precursor
Refseq ID:NP_001230254
Protein GI:343183381
UniProt ID:Q8TD07
mRNA ID:NM_001243325
Length:227
RefSeq Status:
MRRISLTSSPVRLLLFLLLLLIALEIMYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREAERCTGA
SWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDRWIILGAFILL
VLMGIVLICVWWQNGEWQAGLWPLRTS
 
sig_peptide: 1..30
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q8TD07.1)
calculated_mol_wt: 3339
peptide sequence: 
MRRISLTSSPVRLLLFLLLLLIALEIMVGG

mat_peptide: 31..263
product: NKG2D ligand 4
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q8TD07.1)
calculated_mol_wt: 26801
peptide sequence: 
HSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREA
ERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDRWIIL
GAFILLVLMGIVLICVWWQNGEWQAGLWPLRTS

sig_peptide: 1..30
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q8TD07.1)
calculated_mol_wt: 3339
peptide sequence: 
MRRISLTSSPVRLLLFLLLLLIALEIMVGG

mat_peptide: 31..209
product: NKG2D ligand 4 isoform 3
calculated_mol_wt: 20657
peptide sequence: 
HSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREA
ERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTGN

sig_peptide: 1..30
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q8TD07.1)
calculated_mol_wt: 3339
peptide sequence: 
MRRISLTSSPVRLLLFLLLLLIALEIMVGG

mat_peptide: 31..212
product: NKG2D ligand 4 isoform 4
calculated_mol_wt: 21043
peptide sequence: 
HSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREA
ERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTGRRST

sig_peptide: 1..29
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3403
peptide sequence: 
MRRISLTSSPVRLLLFLLLLLIALEIMYN
 
NKG2D ligand 4 isoform 3 precursor
Refseq ID:NP_001230256
Protein GI:343183385
UniProt ID:Q8TD07
mRNA ID:NM_001243327
Length:209
RefSeq Status:
MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRD
LRMLLCDIKPQIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHW
EAMPEPTGN
 
sig_peptide: 1..30
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q8TD07.1)
calculated_mol_wt: 3339
peptide sequence: 
MRRISLTSSPVRLLLFLLLLLIALEIMVGG

mat_peptide: 31..263
product: NKG2D ligand 4
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q8TD07.1)
calculated_mol_wt: 26801
peptide sequence: 
HSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREA
ERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDRWIIL
GAFILLVLMGIVLICVWWQNGEWQAGLWPLRTS

sig_peptide: 1..30
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q8TD07.1)
calculated_mol_wt: 3339
peptide sequence: 
MRRISLTSSPVRLLLFLLLLLIALEIMVGG

mat_peptide: 31..209
product: NKG2D ligand 4 isoform 3
calculated_mol_wt: 20657
peptide sequence: 
HSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREA
ERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTGN
 
NKG2D ligand 4 isoform 4 precursor
Refseq ID:NP_001230257
Protein GI:343183389
UniProt ID:Q8TD07
mRNA ID:NM_001243328
Length:212
RefSeq Status:
MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRD
LRMLLCDIKPQIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHW
EAMPEPTGRRST
 
sig_peptide: 1..30
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q8TD07.1)
calculated_mol_wt: 3339
peptide sequence: 
MRRISLTSSPVRLLLFLLLLLIALEIMVGG

mat_peptide: 31..263
product: NKG2D ligand 4
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q8TD07.1)
calculated_mol_wt: 26801
peptide sequence: 
HSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREA
ERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDRWIIL
GAFILLVLMGIVLICVWWQNGEWQAGLWPLRTS

sig_peptide: 1..30
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q8TD07.1)
calculated_mol_wt: 3339
peptide sequence: 
MRRISLTSSPVRLLLFLLLLLIALEIMVGG

mat_peptide: 31..209
product: NKG2D ligand 4 isoform 3
calculated_mol_wt: 20657
peptide sequence: 
HSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREA
ERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTGN

sig_peptide: 1..30
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q8TD07.1)
calculated_mol_wt: 3339
peptide sequence: 
MRRISLTSSPVRLLLFLLLLLIALEIMVGG

mat_peptide: 31..212
product: NKG2D ligand 4 isoform 4
calculated_mol_wt: 21043
peptide sequence: 
HSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREA
ERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTGRRST
 
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