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MGP006535

UniProt Annotations

Entry Information

Gene Name	retinoic acid early transcript 1E
Protein Entry	N2DL4_HUMAN
UniProt ID	Q8TD07
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8TD07-1; Sequence=Displayed; Name=2; Synonyms=RL-4; IsoId=Q8TD07-2; Sequence=VSP_010441; Name=3; IsoId=Q8TD07-3; Sequence=VSP_010442, VSP_010443; Note=No experimental confirmation available.; Name=RAET1E2; IsoId=Q8TD07-4; Sequence=VSP_045012;
Function	Ligand for the KLRK1 receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes.
Miscellaneous	The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.
Similarity	Belongs to the MHC class I family. {ECO:0000305}.
Subcellular Location	Isoform RAET1E2: Secreted.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Subunit	Binds to KLRK1/NKG2D. Does not interacts with the CMV glycoprotein UL16. {ECO:0000269\|PubMed:15240696}.
Tissue Specificity	Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid. {ECO:0000269\|PubMed:12732206, ECO:0000269\|PubMed:14508119}.