Summary of Study ST000522

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000385. The data can be accessed directly via it's Project DOI: 10.21228/M8902F This work is supported by NIH grant, U2C- DK119886.

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Study IDST000522
Study TitlePlasma metabolomics profiling for fish maturation in blunt snout bream
Study TypeMetabolomics experiment
Study SummaryWe investigated the comprehensive metabolic profiles of plasma among immature females, mature females ready to spawn, as well as already spawned breeders of blunt snout bream (Megalobrama amblycephala). The purpose of this study was to screen out potential biomarkers for sexual mature female M. amblycephala compared to immature female individuals and already spawned breeders. The three groups were set up in this study, including one year old immature females, 2 years old sexually mature females ready to spawning and successfully spawning females of M. amblycephala. The plasma samples were collected to investigate the comprehensive metabolic profiles through UPLC-MS/MS based metabolomics analysis method. According to multivariate and univariate statistical analysis, plasma metabolite profiles of three groups were obviously separated, and the plasma metabolite profiles of immature female M. amblycephala were much more different from mature females ready to spawn as well as already spawned breeders. The differential plasma metabolites from three hormone related pathways including GnRH signaling pathway, steroid hormone biosynthesis and steroid biosynthesis, were further analyzed. A total of 29 metabolites were identified as differential biomarkers associated with the female maturation status
Institute
Huazhong Agricultural University
DepartmentCollege of Fisheries
LaboratoryKey Lab of Freshwater Animal Breeding, Ministry of Agriculture
Last NameZhou
First NameLaiFang
AddressHongshan, Wuhan, 430070 Hubei, China
Email156851836@qq.com
Phone15171617087
Submit Date2016-12-13
Raw Data File Type(s)cdf
Analysis Type DetailLC-MS
Release Date2018-12-11
Release Version1
LaiFang Zhou LaiFang Zhou
https://dx.doi.org/10.21228/M8902F
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Animal; Subject species: Megalobrama amblycephala (Factor headings shown in green)

mb_sample_id local_sample_id Phenotype
SA02725920150724_YU_1_1_61 year old immature
SA02726020150724_YU_1_1_51 year old immature
SA02726120150724_YU_1_1_11 year old immature
SA02726220150724_YU_1_1_101 year old immature
SA02726320150724_YU_1_1_31 year old immature
SA02726420150724_YU_1_1_91 year old immature
SA02726520150724_YU_1_1_221 year old immature
SA02726620150724_YU_1_1_121 year old immature
SA02726720150724_YU_1_1_141 year old immature
SA02726820150724_YU_1_1_111 year old immature
SA02726920150724_YU_2_2_82 years old sexually mature after successfully spawning
SA02727020150724_YU_2_2_92 years old sexually mature after successfully spawning
SA02727120150724_YU_2_2_102 years old sexually mature after successfully spawning
SA02727220150724_YU_2_2_112 years old sexually mature after successfully spawning
SA02727320150724_YU_2_2_62 years old sexually mature after successfully spawning
SA02727420150724_YU_2_2_12 years old sexually mature after successfully spawning
SA02727520150724_YU_2_2_32 years old sexually mature after successfully spawning
SA02727620150724_YU_2_2_22 years old sexually mature after successfully spawning
SA02727720150724_YU_2_2_42 years old sexually mature after successfully spawning
SA02727820150724_YU_2_2_52 years old sexually mature after successfully spawning
SA02727920150724_YU_2_1_52 years old sexually mature without hormone treatment
SA02728020150724_YU_2_1_42 years old sexually mature without hormone treatment
SA02728120150724_YU_2_1_22 years old sexually mature without hormone treatment
SA02728220150724_YU_2_1_62 years old sexually mature without hormone treatment
SA02728320150724_YU_2_1_32 years old sexually mature without hormone treatment
SA02728420150724_YU_2_1_92 years old sexually mature without hormone treatment
SA02728520150724_YU_2_1_102 years old sexually mature without hormone treatment
SA02728620150724_YU_2_1_12 years old sexually mature without hormone treatment
SA02728720150724_YU_2_1_82 years old sexually mature without hormone treatment
SA02728820150724_YU_2_1_72 years old sexually mature without hormone treatment
Showing results 1 to 30 of 30
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