Summary of Study ST002536

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001632. The data can be accessed directly via it's Project DOI: 10.21228/M8RB05 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002536
Study TitleEffectors enabling adaptation to mitochondrial complex I loss in Hürthle cell carcinoma
Study Typecomparison of tumor versus normal tissue
Study SummaryWith the goal of performing RNA-seq and metabolomic profiling, a cohort of fresh frozen oncocytic (Hürthle cell) thyroid carcinoma (HCC) samples was established with confirmation of mtDNA mutation status and chromosomal copy number. This cohort contained 24 oncocytic (Hürthle cell) tumors with 18 cases having matched normal thyroid tissue. Tumor samples included 21 primary tumors comprised of 19 HCC (8 widely invasive, 11 minimally invasive) and 2 oncocytic (Hürthle cell) adenomas as well as 2 locoregional recurrences (LR) and 1 distant metastasis (DM). HCC samples were collected and stored as part of the Mass General Brigham Institutional Review Board (protocol number 2008P001466). Frozen tissue was accessed to create the cohort used in the study.
Institute
Broad Institute of MIT and Harvard
DepartmentMetabolomics Platform
Last NameClish
First NameClary
Address415 Main Street, Cambridge, MA, 02142, USA
Emailclary@broadinstitute.org
Phone617-714-7654
Submit Date2023-03-30
Num Groups2
Total Subjectstumors from 24 subjects and matched normal tissue from a subset of 18 subjects
Num MalesN/A
Num FemalesN/A
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2023-04-17
Release Version1
Clary Clish Clary Clish
https://dx.doi.org/10.21228/M8RB05
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Tissue type
SA254994HC011_Nnormal
SA254995HC010_Nnormal
SA254996HC008_Nnormal
SA254997HC012_Nnormal
SA254998HC009_Nnormal
SA254999HC015_Nnormal
SA255000HC022_Nnormal
SA255001HC021_Nnormal
SA255002HC016_Nnormal
SA255003HC007_Nnormal
SA255004HC014_Nnormal
SA255005HC013_Nnormal
SA255006HC004_Nnormal
SA255007HC002_Nnormal
SA255008HC001_Nnormal
SA255009HC005_Nnormal
SA255010HC003_Nnormal
SA255011HC006_Nnormal
SA255012PREFA3pooled homogenate QC
SA255013PREFA2pooled homogenate QC
SA255014PREFB1pooled homogenate QC
SA255015PREFA1pooled homogenate QC
SA255016PREFB2pooled homogenate QC
SA255017PREFB3pooled homogenate QC
SA255018HC021_Ttumor
SA255019HC020_Ttumor
SA255020HC008_Ttumor
SA255021HC002_Ttumor
SA255022HC023_Ttumor
SA255023HC019_Ttumor
SA255024HC006_Ttumor
SA255025HC024_Ttumor
SA255026HC022_Ttumor
SA255027HC018_Ttumor
SA255028HC012_Ttumor
SA255029HC001_Ttumor
SA255030HC004_Ttumor
SA255031HC011_Ttumor
SA255032HC010_Ttumor
SA255033HC009_Ttumor
SA255034HC013_Ttumor
SA255035HC014_Ttumor
SA255036HC016_Ttumor
SA255037HC017_Ttumor
SA255038HC007_Ttumor
SA255039HC015_Ttumor
SA255040HC003_Ttumor
SA255041HC005_Ttumor
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