Summary of Study ST003159
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001964. The data can be accessed directly via it's Project DOI: 10.21228/M8VD96 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003159 |
| Study Title | Untargeted serum metabolomics in the Parkinson's Environment and Genes (PEG) Study |
| Study Summary | This project aims to evaluate the serum metabolome of Parkinson’s disease (PD) patients relative to unaffected controls in the Parkinson’s Environment and Genes (PEG) Study. Background: Untargeted high-resolution metabolomic profiling provides simultaneous measurement of thousands of metabolites. Metabolic networks based on these data can help uncover disease-related perturbations across interconnected pathways. Objective: Identify metabolic disturbances associated with PD in the PEG population-based study using untargeted metabolomics. Methods: We provide serum-based untargeted metabolomics data derived from liquid chromatography with high-resolution mass spectrometry (LC-HRMS). LC-HRMS detected 4,762 metabolites for analysis (HILIC: 2716 metabolites; C18: 2046 metabolites). |
| Institute | University of California, Los Angeles |
| Department | Neurology |
| Last Name | Paul |
| First Name | Kimberly |
| Address | 710 Westwood Plaza, Los Angeles, CA, 90095, USA |
| kimberlp@ucla.edu | |
| Phone | 310.206.7458 |
| Submit Date | 2023-12-15 |
| Total Subjects | 919 |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-04-23 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN005181 | AN005182 |
|---|---|---|
| Analysis type | MS | MS |
| Chromatography type | HILIC | Reversed phase |
| Chromatography system | Thermo Dionex Ultimate 3000 | Thermo Dionex Ultimate 3000 |
| Column | Waters XBridge BEH Amide (50 x 2.1mm,2.5um) | Thermo Higgins C18 (50 x 2.1mm,3um) |
| MS Type | ESI | ESI |
| MS instrument type | Orbitrap | Orbitrap |
| MS instrument name | Thermo Q Exactive HF hybrid Orbitrap | Thermo Q Exactive HF hybrid Orbitrap |
| Ion Mode | POSITIVE | NEGATIVE |
| Units | log2 transformed intensity | log2 transformed intensity |
MS:
| MS ID: | MS004914 |
| Analysis ID: | AN005181 |
| Instrument Name: | Thermo Q Exactive HF hybrid Orbitrap |
| Instrument Type: | Orbitrap |
| MS Type: | ESI |
| MS Comments: | See attached files |
| Ion Mode: | POSITIVE |
| Capillary Temperature: | 250C |
| Collision Gas: | N2 |
| Dry Gas Flow: | 45 |
| Dry Gas Temp: | 150C |
| Mass Accuracy: | < 3ppm |
| Spray Voltage: | 3500 |
| Activation Parameter: | 5.00E+05 |
| Activation Time: | 118ms |
| Interface Voltage: | S-Lens RF level= 55 |
| Acquisition Parameters File: | EmoryUniversity_HRM_QEHF-MassSpec_092017_v1.pdf |
| Processing Parameters File: | EmoryUniversity_SOP_DataAnalysis_092017_v1.pdf |
| Analysis Protocol File: | Study_Methods.pdf |
| MS ID: | MS004915 |
| Analysis ID: | AN005182 |
| Instrument Name: | Thermo Q Exactive HF hybrid Orbitrap |
| Instrument Type: | Orbitrap |
| MS Type: | ESI |
| MS Comments: | See attached files |
| Ion Mode: | NEGATIVE |
| Capillary Temperature: | 250C |
| Collision Gas: | N2 |
| Dry Gas Flow: | 45 |
| Dry Gas Temp: | 150C |
| Mass Accuracy: | < 3ppm |
| Spray Voltage: | -4000 |
| Activation Parameter: | 5.00E+05 |
| Activation Time: | 118ms |
| Interface Voltage: | S-Lens RF level= 55 |
| Acquisition Parameters File: | EmoryUniversity_HRM_QEHF-MassSpec_092017_v1.pdf |
| Processing Parameters File: | EmoryUniversity_SOP_DataAnalysis_092017_v1.pdf |
| Analysis Protocol File: | Study_Methods.pdf |
