Summary of Study ST001323
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000900. The data can be accessed directly via it's Project DOI: 10.21228/M8BX09 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST001323 |
Study Title | Effect of high-fat diet on serum lipidome in mice |
Study Summary | We analyzed mouse serum samples from a mouse dietary intervention experiment. Briefly, C57BL/6 mice (n=44) were divided into 4 groups (n=11 per group) and fed High-fat diet (HFD), 1% deoxycholic acid (DCA) in drinking water, both, or left as control for 9 months. For quality control, 12 TQC samples and 2 blanks were also included in the analysis (total 58 samples and 6 groups). The two treatments were selected to demonstrate the ability of lipidomics to detect gross changes induced by HFD in the serum lipidome, as well as specific/minor changes induced by the secondary bile acid (DCA) through regulation of liver lipid metabolism. |
Institute | QIMR Berghofer Medical Research Institute |
Last Name | Mohamed |
First Name | Ahmed |
Address | 300 Herston Road |
ahmed.mohamed@qimrberghofer.edu.au | |
Phone | +61738453992 |
Submit Date | 2020-03-02 |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Analysis Type Detail | LC-MS |
Release Date | 2020-03-20 |
Release Version | 1 |
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Combined analysis:
Analysis ID | AN002199 | AN002200 | AN002201 |
---|---|---|---|
Analysis type | MS | MS | MS |
Chromatography type | HILIC | HILIC | HILIC |
Chromatography system | Agilent 1290 Infinity | Agilent 1290 Infinity | Agilent 1290 Infinity |
Column | Agilent HILIC Plus RRHD (100 x 2.1mm, 1.8um) | Agilent HILIC Plus RRHD (100 x 2.1mm, 1.8um) | Agilent HILIC Plus RRHD (100 x 2.1mm, 1.8um) |
MS Type | ESI | ESI | ESI |
MS instrument type | Triple quadrupole | Triple quadrupole | Triple quadrupole |
MS instrument name | Agilent 6490 QQQ | Agilent 6490 QQQ | Agilent 6490 QQQ |
Ion Mode | UNSPECIFIED | POSITIVE | UNSPECIFIED |
Units | intensity | intensity | intensity |