Metabolomics Workbench : NIH Data Repository

MB Sample ID: SA078302

Local Sample ID:	Prednisolone-d0-P4
Subject ID:	SU001204
Subject Type:	Mammal
Subject Species:	Canis lupus familiaris
Taxonomy ID:	9615
Genotype Strain:	Beagle
Age Or Age Range:	8 to 83 months
Weight Or Weight Range:	12.2 to 18.9 kg
Gender:	Male and female
Animal Animal Supplier:	In-house breeding
Animal Feed:	Standard pellet/kibble maintenance diet

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Treatment:

Treatment ID:	TR001219
Treatment Summary:	In the short-term prednisolone group, dogs were treated with 50 mg prednisolone (Streuli Pharma AG, Switzerland) orally twice daily for 3 consecutive days. For the long-term tetracosactide treatment, ALZET osmotic pumps (Durect Corporation, USA) subcutaneously delivering tetracosactide (synthetic ACTH; Bachem AG, Switzerland) were implanted into the dorsolateral neck. New pumps were implanted every 4 weeks. Total infusion time was 25 weeks, with a starting dose of 1.3–1.95 µg/kg/d tetracosactide, which was gradually increased to a final dose of 6–10 µg/kg/d.

Treatment ID:

TR001219

Treatment Summary:

In the short-term prednisolone group, dogs were treated with 50 mg prednisolone (Streuli Pharma AG, Switzerland) orally twice daily for 3 consecutive days. For the long-term tetracosactide treatment, ALZET osmotic pumps (Durect Corporation, USA) subcutaneously delivering tetracosactide (synthetic ACTH; Bachem AG, Switzerland) were implanted into the dorsolateral neck. New pumps were implanted every 4 weeks. Total infusion time was 25 weeks, with a starting dose of 1.3–1.95 µg/kg/d tetracosactide, which was gradually increased to a final dose of 6–10 µg/kg/d.