Summary of Study ST003091
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001920. The data can be accessed directly via it's Project DOI: 10.21228/M8JB09 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003091 |
| Study Title | T cell Immune Escape in Blast Crisis Transformation of Chronic Myeloid Leukemia |
| Study Type | Untargeted metabolomics |
| Study Summary | We report that leukemia secreted cytokines reduce miR-142 levels in T cells, causing T cell loss and exhaustion and therefore promoting CML BC transformation. Our homemade synthetic miR-142 increased T cell antileukemic activity and significantly prolonged the survival of CML BC murine and PDX models. |
| Institute | Translational Genomics Research Institute |
| Department | Integrated Mass Spectrometry Shared Resources |
| Last Name | Pirrotte |
| First Name | Patrick |
| Address | 445 N 5th St Phoenix, AZ 85004 |
| ppirrotte@tgen.org | |
| Phone | 6023438400 |
| Submit Date | 2024-01-26 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-03-01 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN005056 | AN005057 | AN005058 | AN005059 |
|---|---|---|---|---|
| Analysis type | MS | MS | MS | MS |
| Chromatography type | Reversed phase | Reversed phase | HILIC | HILIC |
| Chromatography system | Thermo Dionex Ultimate 3000 | Thermo Dionex Ultimate 3000 | Thermo Dionex Ultimate 3000 | Thermo Dionex Ultimate 3000 |
| Column | Thermo Hypersil Gold C18 (150x 2.1mm, 3uM) | Thermo Hypersil Gold C18 (150x 2.1mm, 3uM) | Waters ACQUITY UPLC BEH Amide (150 x 2.1mm,1.7um) | Waters ACQUITY UPLC BEH Amide (150 x 2.1mm,1.7um) |
| MS Type | ESI | ESI | ESI | ESI |
| MS instrument type | Orbitrap | Orbitrap | Orbitrap | Orbitrap |
| MS instrument name | Thermo Orbitrap Fusion Lumos Tribrid Mass Spectrometer | Thermo Orbitrap Fusion Lumos Tribrid Mass Spectrometer | Thermo Orbitrap Fusion Lumos Tribrid Mass Spectrometer | Thermo Orbitrap Fusion Lumos Tribrid Mass Spectrometer |
| Ion Mode | POSITIVE | NEGATIVE | POSITIVE | NEGATIVE |
| Units | Peak area | Peak area | Peak area | Peak area |
