Summary of Study ST003091
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001920. The data can be accessed directly via it's Project DOI: 10.21228/M8JB09 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003091 |
| Study Title | T cell Immune Escape in Blast Crisis Transformation of Chronic Myeloid Leukemia |
| Study Type | Untargeted metabolomics |
| Study Summary | We report that leukemia secreted cytokines reduce miR-142 levels in T cells, causing T cell loss and exhaustion and therefore promoting CML BC transformation. Our homemade synthetic miR-142 increased T cell antileukemic activity and significantly prolonged the survival of CML BC murine and PDX models. |
| Institute | Translational Genomics Research Institute |
| Department | Integrated Mass Spectrometry Shared Resources |
| Last Name | Pirrotte |
| First Name | Patrick |
| Address | 445 N 5th St Phoenix, AZ 85004 |
| ppirrotte@tgen.org | |
| Phone | 6023438400 |
| Submit Date | 2024-01-26 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-03-01 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Sample Preparation:
| Sampleprep ID: | SP003212 |
| Sampleprep Summary: | Metabolite extraction on T cells were performed using 70% acetonitrile/methanol and 30% water. The metabolite extracts were subjected to untargeted metabolomics using HILIC and reversed phase chromatographies in positive and negative modes. |
| Processing Storage Conditions: | 4℃ |
| Extraction Method: | Polar solvent extraction |
| Extract Storage: | -80℃ |
| Sample Derivatization: | none |
