Summary of Study ST001038

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000695. The data can be accessed directly via it's Project DOI: 10.21228/M8V100 This work is supported by NIH grant, U2C- DK119886.

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Study IDST001038
Study TitleGlobal Metabolomics of the Placenta Reveals Distinct Metabolic Profiles between Maternal and Fetal Placental Tissues Following Delivery in Non-Labored Women
Study TypeTimecourse
Study SummaryWe evaluated the metabolic alterations in maternal and fetal placental tissues from non-labored women undergoing cesarean section using samples collected from 5 min to 24 h following delivery. Using 1H-NMR, we identified 14 metabolites that significantly differed between maternal and fetal placental tissues (FDR-corrected p-value < 0.05), with 12 metabolites elevated in the maternal tissue, reflecting the flux of these metabolites from mother to fetus. In the maternal tissue, 4 metabolites were significantly altered at 15 min, 10 metabolites at 30 min, and 16 metabolites at 1 h postdelivery, while 11 metabolites remained stable over 24 h. In contrast, in the fetal placenta tissue, 1 metabolite was significantly altered at 15 min, 2 metabolites at 30 min, and 4 metabolites at 1 h postdelivery, while 22 metabolites remained stable over 24 h. Our study provides information on the metabolic profiles of maternal and fetal placental tissues delivered by cesarean section and reveals that there are different metabolic alterations in the maternal and fetal tissues of the placenta following delivery.
Institute
University of Florida
DepartmentBiochemistry & Molecular Biology
Last NameJacquelyn
First NameWalejko
AddressR3-226 Academic Research Building, Department of Biochemistry and Molecular Biology, PO Box 100245, Gainesville, FL 32610-0245
Emailjwalejko@ufl.edu
PhoneNA
Submit Date2018-08-20
Num Groups10
Total Subjects226
Publicationsdoi: 10.3390/metabo8010010
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2018-10-10
Release Version1
Walejko Jacquelyn Walejko Jacquelyn
https://dx.doi.org/10.21228/M8V100
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Collection:

Collection ID:CO001071
Collection Summary:The placentas were collected immediately following cesarean delivery, and the tissue specimens were collected from the whole placenta at five time points postdelivery: (1) < 5 min (n = 6); (2) 15 min (n = 13); (3) 30 min (n = 13); (4) 1 h (n = 13); (5) 24 h (n = 13). The tissue specimens were immediately frozen in liquid nitrogen following collection. The whole placentas were kept at 4 °C between sampling time points. Tissue specimens were collected from two areas of the maternal (approximately 1 × 1 cm area; depth of 1 cm) and fetal surfaces (approximately 1 × 1 cm area; depth of 0.3 cm) of each placenta at each time point, resulting in 24 total specimens for the < 5 min time point and 52 total specimens for all other time points. Tissue specimens were immediately frozen in liquid nitrogen following collection and stored at −80 °C until metabolomic analysis
Sample Type:Placenta
Collection Method:Tissue specimens were collected from two areas of the maternal (approximately 1 × 1 cm area; depth of 1 cm) and fetal surfaces (approximately 1 × 1 cm area; depth of 0.3 cm) of each placenta at each time point by cutting with sterile scalpel and forceps on a sterile surface. The tissue specimens were immediately frozen in liquid nitrogen following collection.
Collection Frequency:Tissue specimens were collected from the whole placenta at five time points postdelivery: (1) < 5 min (n = 6); (2) 15 min (n = 13); (3) 30 min (n = 13); (4) 1 h (n = 13); (5) 24 h (n = 13)
Storage Conditions:-80℃
Collection Vials:Nunc 1.8mL Cryogenic tubes (ThermoFisher)
Storage Vials:Nunc 1.8mL Cryogenic tubes (ThermoFisher)
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