Summary of Study ST001038

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000695. The data can be accessed directly via it's Project DOI: 10.21228/M8V100 This work is supported by NIH grant, U2C- DK119886.

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Study IDST001038
Study TitleGlobal Metabolomics of the Placenta Reveals Distinct Metabolic Profiles between Maternal and Fetal Placental Tissues Following Delivery in Non-Labored Women
Study TypeTimecourse
Study SummaryWe evaluated the metabolic alterations in maternal and fetal placental tissues from non-labored women undergoing cesarean section using samples collected from 5 min to 24 h following delivery. Using 1H-NMR, we identified 14 metabolites that significantly differed between maternal and fetal placental tissues (FDR-corrected p-value < 0.05), with 12 metabolites elevated in the maternal tissue, reflecting the flux of these metabolites from mother to fetus. In the maternal tissue, 4 metabolites were significantly altered at 15 min, 10 metabolites at 30 min, and 16 metabolites at 1 h postdelivery, while 11 metabolites remained stable over 24 h. In contrast, in the fetal placenta tissue, 1 metabolite was significantly altered at 15 min, 2 metabolites at 30 min, and 4 metabolites at 1 h postdelivery, while 22 metabolites remained stable over 24 h. Our study provides information on the metabolic profiles of maternal and fetal placental tissues delivered by cesarean section and reveals that there are different metabolic alterations in the maternal and fetal tissues of the placenta following delivery.
Institute
University of Florida
DepartmentBiochemistry & Molecular Biology
Last NameJacquelyn
First NameWalejko
AddressR3-226 Academic Research Building, Department of Biochemistry and Molecular Biology, PO Box 100245, Gainesville, FL 32610-0245
Emailjwalejko@ufl.edu
PhoneNA
Submit Date2018-08-20
Num Groups10
Total Subjects226
Publicationsdoi: 10.3390/metabo8010010
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2018-10-10
Release Version1
Walejko Jacquelyn Walejko Jacquelyn
https://dx.doi.org/10.21228/M8V100
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Timepoint Placenta_Surface Placenta_Area
SA06945780_FC_1515 min Fetal Center
SA06945883_FC_1515 min Fetal Center
SA06945982_FC_1515 min Fetal Center
SA06946084_FC_1515 min Fetal Center
SA069461166_FC_1515 min Fetal Center
SA06946257_FC_1515 min Fetal Center
SA069463167_FC_1515 min Fetal Center
SA06946419_FC_1515 min Fetal Center
SA06946581_FC_1515 min Fetal Center
SA06946616_FC_1515 min Fetal Center
SA06946717_FC_1515 min Fetal Center
SA06946812_FC_1515 min Fetal Center
SA069469166_FP_1515 min Fetal Periphery
SA06947084_FP_1515 min Fetal Periphery
SA06947119_FP_1515 min Fetal Periphery
SA06947217_FP_1515 min Fetal Periphery
SA06947381_FP_1515 min Fetal Periphery
SA06947483_FP_1515 min Fetal Periphery
SA06947580_FP_1515 min Fetal Periphery
SA06947657_FP_1515 min Fetal Periphery
SA06947782_FP_1515 min Fetal Periphery
SA06947818_FP_1515 min Fetal Periphery
SA06947916_FP_1515 min Fetal Periphery
SA069480167_FP_1515 min Fetal Periphery
SA06948184_MC_1515 min Maternal Center
SA06948217_MC_1515 min Maternal Center
SA069483166_MC_1515 min Maternal Center
SA06948412_MC_1515 min Maternal Center
SA06948519_MC_1515 min Maternal Center
SA06948657_MC_1515 min Maternal Center
SA06948781_MC_1515 min Maternal Center
SA06948816_MC_1515 min Maternal Center
SA06948983_MC_1515 min Maternal Center
SA06949080_MC_1515 min Maternal Center
SA06949182_MC_1515 min Maternal Center
SA06949218_MC_1515 min Maternal Center
SA06949319_MP_1515 min Maternal Periphery
SA06949480_MP_1515 min Maternal Periphery
SA06949583_MP_1515 min Maternal Periphery
SA06949682_MP_1515 min Maternal Periphery
SA069497166_MP_1515 min Maternal Periphery
SA06949812_MP_1515 min Maternal Periphery
SA06949957_MP_1515 min Maternal Periphery
SA06950017_MP_1515 min Maternal Periphery
SA06950184_MP_1515 min Maternal Periphery
SA06950216_MP_1515 min Maternal Periphery
SA069503167_MP_1515 min Maternal Periphery
SA06950418_MP_1515 min Maternal Periphery
SA06950581_MP_1515 min Maternal Periphery
SA06940657_FC_601 hr Fetal Center
SA06940718_FC_011 hr Fetal Center
SA06940882_FC_601 hr Fetal Center
SA069409166_FC_601 hr Fetal Center
SA06941081_FC_601 hr Fetal Center
SA06941183_FC_601 hr Fetal Center
SA06941219_FC_011 hr Fetal Center
SA069413167_FC_601 hr Fetal Center
SA06941480_FC_601 hr Fetal Center
SA06941516_FC_011 hr Fetal Center
SA06941684_FC_601 hr Fetal Center
SA06941717_FC_011 hr Fetal Center
SA069418166_FP_601 hr Fetal Periphery
SA06941912_MP_011 hr Fetal Periphery
SA06942083_FP_601 hr Fetal Periphery
SA069421167_FP_601 hr Fetal Periphery
SA06942216_FP_011 hr Fetal Periphery
SA06942381_FP_601 hr Fetal Periphery
SA06942412_FP_011 hr Fetal Periphery
SA06942580_FP_601 hr Fetal Periphery
SA06942617_FP_011 hr Fetal Periphery
SA06942718_FP_011 hr Fetal Periphery
SA06942857_FP_601 hr Fetal Periphery
SA06942919_FP_011 hr Fetal Periphery
SA06943084_FP_601 hr Fetal Periphery
SA06943182_FP_601 hr Fetal Periphery
SA06943257_MC_601 hr Maternal Center
SA06943382_MC_601 hr Maternal Center
SA06943419_MC_011 hr Maternal Center
SA06943512_MC_011 hr Maternal Center
SA06943616_MC_011 hr Maternal Center
SA06943717_MC_011 hr Maternal Center
SA06943881_MC_601 hr Maternal Center
SA069439166_MC_601 hr Maternal Center
SA06944080_MC_601 hr Maternal Center
SA06944183_MC_601 hr Maternal Center
SA06944284_MC_601 hr Maternal Center
SA069443167_MC_601 hr Maternal Center
SA06944418_MC_011 hr Maternal Center
SA06944582_MP_601 hr Maternal Periphery
SA06944618_MP_011 hr Maternal Periphery
SA06944781_MP_601 hr Maternal Periphery
SA06944857_MP_601 hr Maternal Periphery
SA069449166_MP_601 hr Maternal Periphery
SA06945080_MP_601 hr Maternal Periphery
SA069451167_MP_601 hr Maternal Periphery
SA06945217_MP_011 hr Maternal Periphery
SA06945319_MP_011 hr Maternal Periphery
SA06945416_MP_011 hr Maternal Periphery
SA06945583_MP_601 hr Maternal Periphery
SA06945684_MP_601 hr Maternal Periphery
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