Summary of Study ST002200

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001403. The data can be accessed directly via it's Project DOI: 10.21228/M8C99T This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002200
Study TitleHuman Trisome Project Plasma Metabolomics v1
Study SummaryAnalysis of metabolite relative abundance in blood plasma from 316 individuals with trisomy 21 (T21, Down syndrome) and 103 euploid controls. This dataset is part of the Human Trisome Project run by the Linda Crnic Institute for Down Syndrome at the University of Colorado Anschutz Medical Campus.
University of Colorado Denver
LaboratoryPIs - Joaquin Espinosa and Angelo D'Alessandro
Last NameHaines
First NameJulie
Address12801 E 17th Ave, Room 1303, Aurora, Colorado, 80045, USA
Submit Date2022-06-15
Num Groups2
Total Subjects419
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2023-06-15
Release Version1
Julie Haines Julie Haines application/zip

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Collection ID:CO002279
Collection Summary:All study participants were enrolled in the Crnic Institute Human Trisome Project (HTP) under a study protocol approved by the Colorado Multiple Institutional Review Board (NCT02864108, see also Written informed consent was obtained from all study participants or their legal guardians. Data were generated from deidentified biospecimens and linked to demographics and clinical metadata for analysis. Peripheral blood samples were collected into BD Vacutainer K2 EDTA tubes (BD, Cat # 366643) and processed within 2 hrs of blood draw by centrifugation at 700 x g for 15 min to separate plasma, buffy coat (white blood cells, WBCs), and red blood cells (RBCs) which were aliquoted, flash-frozen, and stored at -80°C. Subsequent processing was carried out as described below, with aliquots selected to minimize freeze/thaw cycles.
Sample Type:Blood (plasma)