Summary of Study ST002477
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001600. The data can be accessed directly via it's Project DOI: 10.21228/M8W70C This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002477 |
| Study Title | Neutrophil metabolomics in COVID-19 |
| Study Summary | Severe COVID-19 is characterized by an increase in the number and changes in the function of innate immune cells including neutrophils. However, it is not known how the metabolome of immune cells changes in COVID-19 patients or how metabolic changes may contribute to immune dysfunction. To address these questions, we analyzed the metabolome of neutrophils from patients with severe or mild COVID-19, or healthy controls. We identified widespread dysregulation of neutrophil metabolism with disease progression including in amino acid, redox, and central carbon metabolism. |
| Institute | UT Southwestern Medical Center |
| Last Name | Li |
| First Name | Yafeng |
| Address | 5323 Harry Hines Blvd, Children's Research Institute, Dallas, TX, 75309, USA |
| yafeng.li@utsouthwestern.edu | |
| Phone | 4047696693 |
| Submit Date | 2023-02-14 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzXML, raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-02-26 |
| Release Version | 1 |
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Collection:
| Collection ID: | CO002560 |
| Collection Summary: | COVID-19 patient samples were obtained through the University of Texas Southwestern Medical Center biorepository. Sample collection from COVID-19 patients or healthy controls was performed according to procedures approved by the Institutional Review Board of the University of Texas Southwestern Medical Center (STU-2020-0375 for SARS-CoV2 Biorepository and STU 012014-040 to J. Moreland) and the UT Southwestern Biorepository. Neutrophils were isolated using Ficoll-paque density gradient centrifugation, dextran sedimentation and erythrocyte hypotonic lysis following standard procedures as previously described (Hook et al., 2021). The number of neutrophils in each sample was counted using a microscope before freezing. Samples were stored at -800 C until metabolite extraction. |
| Sample Type: | Neutrophils |
