Summary of Study ST002477

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001600. The data can be accessed directly via it's Project DOI: 10.21228/M8W70C This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002477
Study TitleNeutrophil metabolomics in COVID-19
Study SummarySevere COVID-19 is characterized by an increase in the number and changes in the function of innate immune cells including neutrophils. However, it is not known how the metabolome of immune cells changes in COVID-19 patients or how metabolic changes may contribute to immune dysfunction. To address these questions, we analyzed the metabolome of neutrophils from patients with severe or mild COVID-19, or healthy controls. We identified widespread dysregulation of neutrophil metabolism with disease progression including in amino acid, redox, and central carbon metabolism.
UT Southwestern Medical Center
Last NameLi
First NameYafeng
Address5323 Harry Hines Blvd, Children's Research Institute, Dallas, TX, 75309, USA
Submit Date2023-02-14
Raw Data AvailableYes
Raw Data File Type(s)mzXML, raw(Thermo)
Analysis Type DetailLC-MS
Release Date2023-02-26
Release Version1
Yafeng Li Yafeng Li application/zip

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Combined analysis:

Analysis ID AN004046
Analysis type MS
Chromatography type HILIC
Chromatography system Thermo Scientific QExactive HF-X hybrid quadrupole orbitrap high-resolution mass spectrometer (HRMS)
Column Millipore ZIC-pHILIC column (5 mm, 2.1×150 mm)
MS instrument type Orbitrap
MS instrument name Thermo Q Exactive HF-X Orbitrap
Units MS reading


MS ID:MS003793
Analysis ID:AN004046
Instrument Name:Thermo Q Exactive HF-X Orbitrap
Instrument Type:Orbitrap
MS Comments:Polarity switching was used to detect both positive and negative ions. A pooled quality control (QC) sample was used through the LC-MS run interspersed with the neutrophil samples to monitor the quality and consistency of detection. All samples were randomized to avoid artifactual changes caused by systematic drift. For data acquired with the QExactive, chromatogram peak areas were integrated using Tracefinder (Thermo Scientific) for targeted analysis using an in-house database.