Summary of Study ST002841

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001779. The data can be accessed directly via it's Project DOI: 10.21228/M8RM7K This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002841
Study TitleCollaborative role of YqgC and superoxide dismutase (MnSOD) in manganese intoxication: Replicate Experiment 2
Study TypeTargeted MS Analysis
Study SummaryIn this study, we are validating the mutual impact of yqgC and superoxide dismutase (MnSOD) deletion (YS strain) and resultant hypersensitivity to Manganese (Mn). Our genetic and physiological studies show that Mn intoxication is a result of distinct enzymatic vulnerabilities via alleviated expression of Mg-dependent, chorismate-utilizing enzymes of the menaquinone, siderophore, and tryptophan (MST) family (due to mismetalation).
Institute
Cornell University
DepartmentMedicine
LaboratoryRhee Lab
Last NameSoni
First NameVijay
AddressWeill Cornell Medical College, 413 E 69th St
Emailvis2032@med.cornell.edu
Phone9175391105
Submit Date2023-08-28
Num Groups10
Total Subjects60
Study CommentsNA
PublicationsNA
Raw Data AvailableYes
Raw Data File Type(s)mzML
Chear StudyNA
Analysis Type DetailLC-MS
Release Date2023-09-21
Release Version1
Vijay Soni Vijay Soni
https://dx.doi.org/10.21228/M8RM7K
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Collection:

Collection ID:CO002944
Collection Summary:All strains were grown in LB at 37 ˚C until 0.4 OD600 followed by 60 min treatment with or without 0.15 mM MnCl2 37 ˚C. Cells were pelleted and quenched by resuspending in chilled 0.6 ml of mixtures of acetonitrile:methanol:water (40:40:20).
Collection Protocol ID:NA
Collection Protocol Filename:NA
Collection Protocol Comments:NA
Sample Type:Bacterial cells
Collection Method:NA
Collection Location:NA
Collection Frequency:NA
Collection Duration:NA
Volumeoramount Collected:NA
Storage Conditions:-80℃
Collection Vials:Bead beating tubes
Storage Vials:NA
Additives:NA
Tissue Cell Identification:NA
Tissue Cell Quantity Taken:NA
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