Summary of Study ST002841
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001779. The data can be accessed directly via it's Project DOI: 10.21228/M8RM7K This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002841 |
| Study Title | Collaborative role of YqgC and superoxide dismutase (MnSOD) in manganese intoxication: Replicate Experiment 2 |
| Study Type | Targeted MS Analysis |
| Study Summary | In this study, we are validating the mutual impact of yqgC and superoxide dismutase (MnSOD) deletion (YS strain) and resultant hypersensitivity to Manganese (Mn). Our genetic and physiological studies show that Mn intoxication is a result of distinct enzymatic vulnerabilities via alleviated expression of Mg-dependent, chorismate-utilizing enzymes of the menaquinone, siderophore, and tryptophan (MST) family (due to mismetalation). |
| Institute | Cornell University |
| Department | Medicine |
| Laboratory | Rhee Lab |
| Last Name | Soni |
| First Name | Vijay |
| Address | Weill Cornell Medical College, 413 E 69th St |
| vis2032@med.cornell.edu | |
| Phone | 9175391105 |
| Submit Date | 2023-08-28 |
| Num Groups | 10 |
| Total Subjects | 60 |
| Study Comments | NA |
| Publications | NA |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Chear Study | NA |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-09-21 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
| Project ID: | PR001779 |
| Project DOI: | doi: 10.21228/M8RM7K |
| Project Title: | Collaborative role of YqgC and superoxide dismutase (MnSOD) in manganese intoxication |
| Project Type: | LC-MS targettged analysis |
| Project Summary: | Bacterial metal ion homeostasis is strongly regulated by various metalloregulators. This project is focused on the role of yqgC-soda operon of B. subtilis in Manganese (Mn) ion metal homeostasis and the dependencies of these genes to maintain bacterial survival in the excess of Mn. |
| Institute: | Weill Cornell Medicine |
| Department: | Medicine |
| Laboratory: | Rhee Lab |
| Last Name: | Soni |
| First Name: | Vijay |
| Address: | 413 E 69TH STREET, Belfer Research Building, New York, New York, 10021, USA |
| Email: | vis2032@med.cornell.edu |
| Phone: | 9175391105 |
| Funding Source: | R35GM122461, NIAID:R25 AI140472 |
| Project Comments: | NA |
| Publications: | NA |
| Contributors: | Ankita J. Sachla, Vijay Soni, Yuanchan Luo, Kyu Y. Rhee, John D. Helmann |
