Summary of Study ST000883
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000612. The data can be accessed directly via it's Project DOI: 10.21228/M8FM7S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST000883 |
| Study Title | Breathprinting Reveals Malaria-Associated Biomarkers and Mosquito Attractants |
| Study Summary | Current evidence suggests that malaria infection could alter patient breath metabolites, a phenomenon that could be exploited to create a breath-based diagnostic test. Indications include the preferential attraction of the Anopheles mosquito vector upon infection and a distinct breath profile with the progression of experimental, sub-microscopic malaria. However, these observations have yet to be extended to the clinic. To investigate whether natural human malaria infection leads to a characteristic breath profile, we performed a field study in Malawi. Breath volatiles from pediatric patients with and without uncomplicated falciparum malaria were analyzed by thermal desorption-gas chromatography/mass spectrometry. Using an unbiased, correlation-based analysis, we find that children with malaria have a distinct shift in overall breath composition. Leveraging these differences, highly accurate classification of infection status was achieved with a suite of six compounds. In addition, we find that malaria-infected children have significantly higher breath levels of two mosquito-attractant terpenes, α-pinene and 3-carene. Thus, our work attests to the viability of breath analysis for malaria diagnosis, identifies candidate compounds for follow-up studies, and identifies biologically plausible chemical mediators for increased mosquito attraction to malaria-infected patients. |
| Institute | Washington University in St. Louis |
| Department | School of Medicine |
| Last Name | Schaber |
| First Name | Chad |
| Address | 4938 Parkview Place, MPRB/FLoor 6, Entry 5, St. Louis, MO, 63110, USA |
| chadschaber@wustl.edu | |
| Phone | 3142862040 |
| Submit Date | 2017-10-08 |
| Raw Data File Type(s) | cdf |
| Analysis Type Detail | GC-MS |
| Release Date | 2018-02-05 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
| mb_sample_id | local_sample_id | Malaria Infection Status |
|---|---|---|
| SA051168 | Patient 14 | Negative |
| SA051169 | Patient 13 | Negative |
| SA051170 | Patient 12 | Negative |
| SA051171 | Patient 15 | Negative |
| SA051172 | Patient 16 | Negative |
| SA051173 | Patient 1 | Negative |
| SA051174 | Patient 17 | Negative |
| SA051175 | Patient 11 | Negative |
| SA051176 | Patient 18 | Negative |
| SA051177 | Patient 4 | Negative |
| SA051178 | Patient 3 | Negative |
| SA051179 | Patient 10 | Negative |
| SA051180 | Patient 5 | Negative |
| SA051181 | Patient 2 | Negative |
| SA051182 | Patient 9 | Negative |
| SA051183 | Patient 6 | Negative |
| SA051184 | Patient 8 | Negative |
| SA051185 | Patient 7 | Negative |
| SA051186 | Patient 31 | Positive |
| SA051187 | Patient 29 | Positive |
| SA051188 | Patient 32 | Positive |
| SA051189 | Patient 30 | Positive |
| SA051190 | Patient 34 | Positive |
| SA051191 | Patient 28 | Positive |
| SA051192 | Patient 35 | Positive |
| SA051193 | Patient 33 | Positive |
| SA051194 | Patient 23 | Positive |
| SA051195 | Patient 21 | Positive |
| SA051196 | Patient 20 | Positive |
| SA051197 | Patient 19 | Positive |
| SA051198 | Patient 22 | Positive |
| SA051199 | Patient 24 | Positive |
| SA051200 | Patient 26 | Positive |
| SA051201 | Patient 25 | Positive |
| SA051202 | Patient 27 | Positive |
| Showing results 1 to 35 of 35 |
