Summary of Study ST001369

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000922. The data can be accessed directly via it's Project DOI: 10.21228/M8HH5M This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001369
Study TitleGrass pollen sublingual immunotherapy treatment induces transcriptomic and metabolic changes due to AIT treatment
Study Summary47 patients were enrolled in a double-blind, placebo-controlled, multicenter trial using with GRAZAX® (Phleum pretense) during 2 years of therapy (T2). Immunological assays such as sIgE, sIgG4 and ISAC were carried out to the 31 patients who finished the trial. Additionally, serum and PBMCs samples from these samples were analyzed by metabolomics and transcriptomics, respectively. Based on their sensitization level, 22 patients were grouped in Mono and Poli groups, excluding epithelial allergic patients. Individuals were studied based on their treatment in Active and Placebo and their sensitization level. For metabolomics, samples were analyzed by Liquid and Gas Chromatography coupled to Mass Spectrometry (LC-MS and GC-MS, respectively).
Institute
Institute of Applied Molecular Medicine;The Centre of Metabolomics and Bioanalysis
Last NameObeso Montero
First NameDavid
AddressAvda. Monteprincipe s/n 28668 Boadilla del Monte, Madrid, España
Emaildavid.obesomontero@beca.ceu.es
PhoneTlf: 91 372 47 00 ext. 4662
Submit Date2020-03-27
Num Groups2 main groups: Active and Placebo, and 2 subgroups: Monosensitized and Polisensitized patients.
Total Subjects22
Study Commentshttps://www.ceu.es;http://www.metabolomica.uspceu.es
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailGC-MS/LC-MS
Release Date2020-09-29
Release Version1
David Obeso Montero David Obeso Montero
https://dx.doi.org/10.21228/M8HH5M
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Treatment Sensitization
SA099421P28_t0Active Mono
SA099422P27_t0Active Mono
SA099423P1_t0Active Mono
SA099424P27_T2Active Mono
SA099425P28_t2Active Mono
SA099426P17_t0Active Mono
SA099427P17_t2Active Mono
SA099428P1_t2Active Mono
SA099429P11_t2Active Poli
SA099430P15_t0Active Poli
SA099431P13_t0Active Poli
SA099432P12_t0Active Poli
SA099433P11_t0Active Poli
SA099434P12_t2Active Poli
SA099435P13_t2Active Poli
SA099436P15_t2Active Poli
SA099437P22_t2Placebo Mono
SA099438P16_t2Placebo Mono
SA099439P25_T2Placebo Mono
SA099440P26_t2Placebo Mono
SA099441P30_t0Placebo Mono
SA099442P22_t0Placebo Mono
SA099443P21_t0Placebo Mono
SA099444P21_t2Placebo Mono
SA099445P16_t0Placebo Mono
SA099446P26_t0Placebo Mono
SA099447P25_t0Placebo Mono
SA099448P30_t2Placebo Mono
SA099449P3_t0Placebo Poli
SA099450P4_t0Placebo Poli
SA099451P24_t2Placebo Poli
SA099452P8_t0Placebo Poli
SA099453P23_t2Placebo Poli
SA099454P9_t2Placebo Poli
SA099455P24_t0Placebo Poli
SA099456P23_t0Placebo Poli
SA099457P20_t0Placebo Poli
SA099458P14_t0Placebo Poli
SA099459P3_t2Placebo Poli
SA099460P4_t2Placebo Poli
SA099461P9_t0Placebo Poli
SA099462P14_t2Placebo Poli
SA099463P8_t2Placebo Poli
SA099464P20_t2Placebo Poli
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