Summary of Study ST002527

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001627. The data can be accessed directly via it's Project DOI: 10.21228/M8D434 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002527
Study TitleHPLC-MS-MS analysis amino acid levels in PDAC IF samples upon arginase inhibition
Study SummaryTo test the hypothesis that myeloid arginase-1 activity could be responsible for pancreatic ductal adenocarninoma microenvironmental arginine starvation (PMID: 30990168), we generated orthotopic allograft mPDAC tumors in a mouse model with myeloid specific Arg1 knockout (LysM-Cre+/+-; Arg1fl/fl) and control animals (Arg1fl/fl). We also tested this with pharmacological inhibition of arginase-1 with the small-molecule inhibitor CB-1158. We then isolated IF from these tumors at end-stage and measured the levels of amino acids including arginine and ornithine in these samples.
Institute
University of Chicago
Last NameApiz Saab
First NameJuan
Address929 E. 57th St.
Emailjapizsaab@uchicago.edu
Phone7738346506
Submit Date2022-08-05
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2023-04-13
Release Version1
Juan Apiz Saab Juan Apiz Saab
https://dx.doi.org/10.21228/M8D434
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Genotype Treatment
SA254603T202Arg1fl/fl NA
SA254604T237Arg1fl/fl NA
SA254605T111Arg1fl/fl NA
SA254606T217Arg1fl/fl NA
SA254607T236LysM-Cre+/+; Arg1fl/fl NA
SA254608T203LysM-Cre+/+; Arg1fl/fl NA
SA254609T215LysM-Cre+/+; Arg1fl/fl NA
SA254610T298LysM-Cre+/+; Arg1fl/fl NA
SA254611T214LysM-Cre+/+; Arg1fl/fl NA
SA254612T233LysM-Cre+/+; Arg1fl/fl NA
SA254613T234LysM-Cre+/+; Arg1fl/fl NA
SA254614T245NA CB1158
SA254615T242NA CB1158
SA254616T241NA CB1158
SA254617T244NA CB1158
SA254618T231NA CB1158
SA254619T238NA Vehicle
SA254620T239NA Vehicle
SA254621T400NA Vehicle
SA254622T282NA Vehicle
SA254623T278NA Vehicle
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