Summary of Study ST000315
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000254. The data can be accessed directly via it's Project DOI: 10.21228/M8Z88C This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000315 |
| Study Title | Metabolomics and Childhood Obesity: A Pilot and Feasibility Study With Multiple Phenotypic Anchors |
| Study Type | Metabolomics |
| Study Summary | “Metabolomics” is a powerful new analytical approach for measuring and evaluating all small and intermediate sized metabolites in a variety of tissues or samples in conditions of health and disease. The purpose of this research is to determine if “metabolomics” can be used to address several important unanswered questions about obesity in children. First we will use metabolomics to identify patterns of metabolites in blood that are unique to obese children. We will then determine if these patterns are predictive of excessive weight gain and/or poor weight loss response in non-obese and obese children enrolled in an exercise program. |
| Institute | University of North Carolina |
| Department | Systems and Translational Sciences |
| Laboratory | Sumner Lab |
| Last Name | Sumner |
| First Name | Susan |
| Address | Eastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081 |
| susan_sumner @unc.edu | |
| Phone | 704-250-5066 |
| Submit Date | 2015-12-31 |
| Total Subjects | 219 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | fid |
| Analysis Type Detail | NMR |
| Release Date | 2016-12-31 |
| Release Version | 1 |
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Project:
| Project ID: | PR000254 |
| Project DOI: | doi: 10.21228/M8Z88C |
| Project Title: | Metabolomics and Childhood Obesity: A Pilot and Feasibility Study With Multiple Phenotypic Anchors |
| Project Summary: | “Metabolomics” is a powerful new analytical approach for measuring and evaluating all small and intermediate sized metabolites in a variety of tissues or samples in conditions of health and disease. The purpose of this research is to determine if “metabolomics” can be used to address several important unanswered questions about obesity in children. First we will use metabolomics to identify patterns of metabolites in blood that are unique to obese children. We will then determine if these patterns are predictive of excessive weight gain and/or poor weight loss response in non-obese and obese children enrolled in an exercise program. This knowledge will help us understand why some children are destined to become obese and/or are poorly responsive to treatment. This will help identify children who might need more aggressive, expensive or personally tailored obesity treatments. Second we plan to use metabolomics to identify metabolic signals specifically associated with the early initiation of atherosclerosis (and hence increased risk for cardiovascular disease [CVD]) in obese children. We expect that this knowledge will ultimately lead to better early risk assessment and opportunities for risk reduction in both obese and non-obese children than allowed by current clinical practices. Finally the knowledge gained from this research could be applied in the future to prospectively assess – and therefore proactively manage ~ a broad range of risk factors in large numbers of young children in a rational and cost effective manner. |
| Institute: | East Carolina University |
| Department: | Pediatric Healthy Weight Research and Treatment Center |
| Last Name: | Collier |
| First Name: | David |
| Address: | 174 Warren Life Sciences Bldg, East Carolina University, Greenville NC 27834 |
| Email: | Collierd@ecu.edu |
| Phone: | 252-744-3538 |
