Summary of Study ST001940
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001228. The data can be accessed directly via it's Project DOI: 10.21228/M80120 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST001940 |
| Study Title | Cognitive Behavioral Therapy for Irritable Bowel Syndrome Induces Bidirectional Alterations in the Brain-Gut-Microbiome Axis Associated with Gastrointestinal Symptom Improvement |
| Study Summary | 34 Rome III-diagnosed IBS patients receiving CBT were drawn from the Irritable Bowel Syndrome Outcome Study (IBSOS; ClinicalTrials.gov NCT00738920). Fecal samples were collected at baseline and post-treatment for 16S rRNA gene sequencing, untargeted metabolomics, and measurement of short chain fatty acids. Multimodal neuroimaging was performed at baseline and post-treatment. |
| Institute | University of California, Los Angeles |
| Department | Division of Digestive Diseases |
| Laboratory | Jacobs Laboratory |
| Last Name | Jacobs |
| First Name | Jonathan |
| Address | 10833 Le Conte Ave, Los Angeles, CA 90095 |
| JJacobs@mednet.ucla.edu | |
| Phone | 310-825-9333 |
| Submit Date | 2021-09-01 |
| Total Subjects | 34 |
| Num Males | 6 |
| Num Females | 28 |
| Raw Data Available | Yes |
| Analysis Type Detail | LC-MS |
| Release Date | 2022-03-01 |
| Release Version | 1 |
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Project:
| Project ID: | PR001228 |
| Project DOI: | doi: 10.21228/M80120 |
| Project Title: | Cognitive Behavioral Therapy for Irritable Bowel Syndrome Induces Bidirectional Alterations in the Brain-Gut-Microbiome Axis Associated with Gastrointestinal Symptom Improvement |
| Project Summary: | There is growing recognition that bidirectional signaling between the digestive tract and the brain contributes to irritable bowel syndrome (IBS). We recently showed in a large randomized controlled trial that cognitive behavioral therapy (CBT) reduces IBS symptom severity. This study investigated whether baseline brain and gut microbiome parameters predict CBT response and whether response is associated with changes in the brain-gut-microbiome (BGM) axis. |
| Institute: | University of California, Los Angeles |
| Department: | Division of Digestive Diseases |
| Laboratory: | Jacobs Laboratory |
| Last Name: | Jacobs |
| First Name: | Jonathan |
| Address: | 10833 Le Conte Ave., Los Angeles, CA 90095 |
| Email: | JJacobs@mednet.ucla.edu |
| Phone: | 310-825-9333 |
