Summary of Study ST001951
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001238. The data can be accessed directly via it's Project DOI: 10.21228/M8PH6J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST001951 |
| Study Title | Quantification of ω-3 fatty acids and their derivatives in lungs from hypoxia-induced pulmonary hypertension (PH) mice. |
| Study Summary | Using a liquid chromatography tandem mass spectrometry (LC-MS/MS) system, we quantified the ω-3 fatty acid (EPA and DHA) metabolites in the lung tissues of mice with PH induced by chronic hypoxia (10% oxygen concentration). |
| Institute | University of Tokyo |
| Last Name | Kono |
| First Name | Nozomu |
| Address | 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan |
| nozomu@mol.f.u-tokyo.ac.jp | |
| Phone | +81-3-5841-4723 |
| Submit Date | 2021-10-17 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2022-03-31 |
| Release Version | 1 |
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Project:
| Project ID: | PR001238 |
| Project DOI: | doi: 10.21228/M8PH6J |
| Project Title: | Analysis of ω-3 fatty acids and their derivatives in lungs from hypoxia-induced pulmonary hypertension (PH) mice. |
| Project Summary: | Pulmonary arterial hypertension (PAH) is a rare, fatal disease that causes idiopathic pulmonary artery stenosis, which leads to increased pulmonary artery pressure and this chronic pressure-overload eventually results in right heart failure and death. Although the available therapies for PH have notably improved the survival of patients with PAH, there is still a significant portion of patients who do not achieve the expected efficacy. Here, in order to identify bioactive lipids which are protective against pulmonary hypertension (PH), we performed comprehensive lipidomic analysis of lung samples from hypoxia-induced PH mice. |
| Institute: | University of Tokyo |
| Last Name: | Kono |
| First Name: | Nozomu |
| Address: | 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan |
| Email: | nozomu@mol.f.u-tokyo.ac.jp |
| Phone: | +81-3-5841-4723 |
