Summary of Study ST002069
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001311. The data can be accessed directly via it's Project DOI: 10.21228/M88113 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002069 |
| Study Title | Systemic impact of the expression of the mitochondrial alternative oxidase on Drosophila development |
| Study Summary | Despite the beneficial effects shown when the mitochondrial alternative oxidase AOX from Ciona intestinalis (Tunicata: Ascidiacea) is xenotopically expressed in mammalian and insect models, important detrimental outcomes have also been reported, raising concerns regarding its envisioned deployment as a therapy enzyme for human mitochondrial and related diseases. We have shown previously that AOX-expressing flies present a dramatic drop in pupal viability when the larvae are cultured on a low nutrient (LN) diet, indicating that AOX interferes with normal developmental metabolism. Here, we applied the metabolomics approach to gain insights into the molecular basis of the fatal developmental interaction between AOX expression and LN diet. We investigated the whole-body metabolome of AOX-expressing and control larvae cultured on SD and LN diets. |
| Institute | Tampere University |
| Department | Faculty of Medicine and Health Technology |
| Last Name | Dufour |
| First Name | Eric |
| Address | Arvo Ylpön katu 34, 33520 Tampere, Finlândia |
| eric.dufour@tuni.fi | |
| Phone | +358 (0)50 413 0493 |
| Submit Date | 2022-01-29 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzXML |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-01-10 |
| Release Version | 1 |
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Project:
| Project ID: | PR001311 |
| Project DOI: | doi: 10.21228/M88113 |
| Project Title: | Molecular alterations caused by mitochondrial alternative oxidase (AOX) expression in Drosophila melanogaster development |
| Project Summary: | Whole-body metabolome of AOX-expressing and control larvae of Drosophila melanogaster cultured on standard (SD) and low-nutrient (LN) diets |
| Institute: | Tampere University |
| Department: | Faculty of Medicine and Health Technology |
| Last Name: | Dufour |
| First Name: | Eric |
| Address: | Arvo Ylpön katu 34, 33520 Tampere, Finlândia |
| Email: | eric.dufour@tuni.fi |
| Phone: | +358 (0)50 413 0493 |
| Funding Source: | European Union (Marie Curie International Incoming Fellowship GA328988 |
