Summary of Study ST002494
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001610. The data can be accessed directly via it's Project DOI: 10.21228/M8KT5B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002494 |
| Study Title | Disrupted intestinal microbiota contributes to the pathogenesis of anorexia nervosa (Part 1) |
| Study Summary | Anorexia nervosa (AN) is an eating disorder with a high mortality affecting about 1% of women, where no evidence-based effective treatment exists. The pathogenesis likely involves genetic and environmental alterations. We hypothesized that a disrupted gut microbiota contributes to AN pathogenesis. In analyses comparing 70 AN with 77 healthy females, we found multiple taxa, functional modules, structural variants and growth rates of bacterial gut microbiota, and viral gut microbiota that were altered in AN with parts of these perturbations linked to estimates of eating behavior and mental health. In silico, causal inference analyses implied serum bacterial metabolites mediated parts of the impact of altered gut microbiota on AN behavior, and in vivo, three independent fecal microbiota transplantation from AN cases to germ-free mice under energy restricted feeding mirroring AN eating behavior consistently induced a lower body weight gain and hypothalamic and adipose tissue gene expressions related to aberrant energy metabolism and eating and mental behavior. |
| Institute | Örebro University |
| Last Name | McGlinchey |
| First Name | Aidan |
| Address | Room 2217, Södra Grev Rosengatan 30, 70362 Örebro |
| aidan.mcglinchey@oru.se | |
| Phone | +46 0736485638 |
| Submit Date | 2022-05-18 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | GC-MS |
| Release Date | 2023-02-27 |
| Release Version | 1 |
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Project:
| Project ID: | PR001610 |
| Project DOI: | doi: 10.21228/M8KT5B |
| Project Title: | Disrupted intestinal microbiota contributes to the pathogenesis of anorexia nervosa |
| Project Summary: | Anorexia nervosa (AN) is an eating disorder with a high mortality affecting about 0.5% of women, where no evidence-based effective treatment exists. The pathogenesis likely involves genetic and environmental alterations. We hypothesized that a disrupted gut microbiota contributes to AN pathology. In analyses comparing 70 AN with 77 healthy females, we found multiple taxa, functional modules, structural variants and growth rates of bacterial gut microbiota, and viral gut microbiota that were altered in AN with parts of these perturbations linked to estimates of eating behavior and mental health. In silico, causal inference analyses implied bacterial metabolites mediated parts of the impact of altered gut microbiota on AN behavior, and in vivo, fecal microbiota transplantation from AN cases to germ-free mice induced a lower body weight and hypothalamic and adipose tissue gene expressions related to aberrant energy metabolism and eating and mental behavior. |
| Institute: | Örebro University |
| Last Name: | McGlinchey |
| First Name: | Aidan |
| Address: | Room 2217, Södra Grev Rosengatan 30, 70362 Örebro |
| Email: | aidan.mcglinchey@oru.se |
| Phone: | +46 0736485638 |
