Summary of Study ST000930
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000644. The data can be accessed directly via it's Project DOI: 10.21228/M8F380 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000930 |
| Study Title | Define alterations in the gut metabolome of mice infected with C. difficile |
| Study Type | Time course experiment |
| Study Summary | C57BL/6 mice were treated with antibiotics to make them susceptible to C. difficile. Mice were challenged with C. difficile and the infection was monitored for 30 hours post challenge. Mice were sacrificed at 0 hr, 12 hr, 24 hr, and 30 hr post challenge with C. difficile and gut content was collected for untargeted metabolomic analysis. The aim of this project was to define the gut metabolome throughout C. difficile infection. |
| Institute | North Carolina State University |
| Department | PHP |
| Laboratory | Theriot |
| Last Name | Theriot |
| First Name | Casey |
| Address | 1051 William Moore Drive |
| cmtherio@ncsu.edu | |
| Phone | 919-513-0711 |
| Submit Date | 2018-02-26 |
| Num Groups | 4 |
| Total Subjects | 31 |
| Num Males | 16 |
| Num Females | 15 |
| Analysis Type Detail | LC-MS |
| Release Date | 2018-03-15 |
| Release Version | 1 |
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Treatment:
| Treatment ID: | TR000983 |
| Treatment Summary: | Mice were treated with cefoperazone in their drinking water for 5 days with a two day washout before being challenged with C. difficile spores. Mice were euthanized at time 0hr, prior to C. difficile challenge, and post challenge at 12, 24, and 30 hr. The cecum of mice was collected, flash frozen and stored in the -80C until processing. |
