Summary of Study ST001638
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001035. The data can be accessed directly via it's Project DOI: 10.21228/M8X39Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST001638 |
Study Title | Metabolomics analysis of Vehicle (DMSO/PBS; (1:1) v/v) and DRB18 (10 mg/kg) treated A549 xenograft tumors |
Study Type | Anticancer compound treatment experiment in vivo |
Study Summary | A549 xenograft tumors were treated with (DMSO/PBS; (1:1) v/v) and DRB18 (10 mg/kg) for 5 weeks. The mice were then sacrificed and tumors were then excised. Tumors were then subjected to untargeted metabolomics analysis. |
Institute | Ohio University |
Department | Biological Sciences |
Laboratory | Dr. Xiaozhuo Chen, Edison biotechnology Institute |
Last Name | Shriwas |
First Name | Pratik |
Address | 172 Water Tower, Building 25, The Ridges, Konnekar Research Centerm Athens Ohio - 45701, USA |
ps774614@ohio.edu | |
Phone | 7406033801 |
Submit Date | 2020-12-07 |
Num Groups | 2 |
Total Subjects | 20 |
Num Males | 20 |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Analysis Type Detail | LC-MS |
Release Date | 2021-04-01 |
Release Version | 1 |
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Treatment:
Treatment ID: | TR001728 |
Treatment Summary: | Male NU/J nude mice of 3 to 4 weeks of age were purchased from The Jackson Laboratory and were fed with the Irradiated Teklad Global 19% protein rodent diet from Harlan Laboratories. The protocol for cell injection, treatment administration, weekly tumor measurement, animal euthanasia and final tumor measurements were performed as described previously (unless stated otherwise) (31). Tumor cell–injected mice were randomly divided into 2 groups: control group (n = 10) treated with PBS/DMSO (1:1, v/v) and 10 mg/kg (body weight) DRB18 treatment group (n = 10) dissolved in PBS/DMSO solution (1:1, v/v). Mice were given intraperitoneal injection with either PBS/DMSO vehicle or compound DRB18 (10 mg/kg) thrice a week for 5 weeks. |
Treatment Protocol Filename: | prats1988_20201207_Invivo_collection_and_preparation_method.docx |
Treatment: | Anticancer compound in xenograft tumors via i.p. |
Treatment Compound: | Control (DMSO/PBS; 1:1 v/v) and DRB18 (10mg/kg body weight dissolved in DMSO/PBS; 1:1 v/v) |
Treatment Route: | i.p. |
Treatment Dose: | 10 mg/kg body weight |
Treatment Dosevolume: | 100ul |
Treatment Vehicle: | DMSO/PBS (1:1; v/v) |