Summary of Study ST002499

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001272. The data can be accessed directly via it's Project DOI: 10.21228/M89402 This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002499
Study TitleMetabolomics analysis of stress erythroid progenitors (Part 2)
Study SummaryA time course study to assess the intracellular metabolic changes of splenic Kit+ stress erythroid progenitors
Pennsylvania State University
DepartmentVeterinary and Biomedical Sciences
LaboratoryPaulson Lab
Last NameRuan
First NameBaiye
Address228 AVBS Building Shortlidge Road University Park, PA 16802
Submit Date2023-02-23
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2023-03-22
Release Version1
Baiye Ruan Baiye Ruan application/zip

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Treatment ID:TR002608
Treatment Summary:Phenylhydrazine (PHZ)-induced hemolytic anemia To induce acute hemolytic anemia, age- and sex-matched mice were injected intraperitoneally with a single dose (100 mg/kg body weight) of freshly prepared phenylhydrazine (Sigma-Aldrich, dissolved in PBS). Mice were sacrificed at indicated time points for spleen sample collection and Kit cell enrichment. Brucella abortus-induced inflammatory anemia Heat-killed Brucella abortus (HKBA, strain 1119-3) was used to induce anemia of inflammation following a previously described method(1). To induce stress erythropoiesis, age- and sex-matched mice were administered with 5 x 108 particles of HKBA via intraperitoneal injection.Mice were sacrificed at indicated time points for spleen sample collection and Kit cell enrichment.