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MGP002242

Record overview

MGPD IDMGP002242
Gene ID5196
SpeciesHomo sapiens (Human)
Gene Nameplatelet factor 4
Gene Symbol PF4
SynonymsPF-4; CXCL4; SCYB4;
Alternate namesplatelet factor 4; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; iroplact; oncostatin-A;
Chromosome4
Map Location4q12-q21
SummaryThis gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]
OrthologsView orthologs and multiple alignments for PF4

Proteins

platelet factor 4 precursor
Refseq ID:NP_002610
Protein GI:4505733
UniProt ID:P02776
mRNA ID:NM_002619
Length:101
RefSeq Status:
MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLE
S
 
sig_peptide: 1..31
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3094
peptide sequence: 
MSSAAGFCASRPGLLFLGLLLLPLVVAFASA

mat_peptide: 32..101
product: Platelet factor 4
experiment: DESCRIPTION:antimicrobial peptide[PMID: 23245326]
calculated_mol_wt: 7769
peptide sequence: 
EAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES

mat_peptide: 48..101
product: Platelet factor 4, short form
experiment: DESCRIPTION:antimicrobial peptide[PMID: 23245326]
calculated_mol_wt: 6033
peptide sequence: 
SQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES
 
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