MGP Database

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MGP002242

Ontology/Pathway Information

Entrez Gene ID5196
Gene Nameplatelet factor 4
Gene Symbol PF4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005576 NAS:UniProtKBCextracellular region
GO:0005615 IBA:GO_CentralCextracellular space
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0008009 TAS:UniProtKBFchemokine activity
GO:0048248 IDA:UniProtKBFCXCR3 chemokine receptor binding
GO:0008201 IDA:UniProtKBFheparin binding
GO:0007596 TAS:ReactomePblood coagulation
GO:0070098 IBA:GO_CentralPchemokine-mediated signaling pathway
GO:0019221 IDA:UniProtKBPcytokine-mediated signaling pathway
GO:0007186 IBA:GO_CentralPG-protein coupled receptor signaling pathway
GO:0006955 IBA:GO_CentralPimmune response
GO:0006954 IBA:GO_CentralPinflammatory response
GO:0030595 IDA:UniProtKBPleukocyte chemotaxis
GO:0016525 IDA:UniProtKBPnegative regulation of angiogenesis
GO:0045918 IDA:BHF-UCLPnegative regulation of cytolysis
GO:2001240 IDA:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0045653 IDA:UniProtKBPnegative regulation of megakaryocyte differentiation
GO:0045347 IDA:BHF-UCLPnegative regulation of MHC class II biosynthetic process
GO:0030168 IDA:UniProtKBPplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0043950 IDA:UniProtKBPpositive regulation of cAMP-mediated signaling
GO:0030816 IDA:UniProtKBPpositive regulation of cAMP metabolic process
GO:0010628 IDA:BHF-UCLPpositive regulation of gene expression
GO:0002690 IBA:GO_CentralPpositive regulation of leukocyte chemotaxis
GO:0010744 IDA:BHF-UCLPpositive regulation of macrophage derived foam cell differentiation
GO:0045651 IDA:BHF-UCLPpositive regulation of macrophage differentiation
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0032760 IDA:BHF-UCLPpositive regulation of tumor necrosis factor production
GO:0042127 IDA:UniProtKBPregulation of cell proliferation
GO:0032496 IBA:GO_CentralPresponse to lipopolysaccharide
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_12051Cell surface interactions at the vascular wall
REACT_15344Chemokine receptors bind chemokines
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_1439Common Pathway
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_19231G alpha (i) signalling events
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_604Hemostasis
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14819Peptide ligand-binding receptors
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
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