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MGP002242

UniProt Annotations

Entry Information
Gene Nameplatelet factor 4
Protein EntryPLF4_HUMAN
UniProt IDP02776
SpeciesHuman
Comments
Comment typeDescription
FunctionReleased during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. {ECO:0000269|PubMed:7644496}.
Mass SpectrometryMass=6033; Method=Electrospray; Range=48-101; Note=Short form.; Evidence={ECO:0000269|PubMed:7644496};
Mass SpectrometryMass=7765; Method=Electrospray; Range=32-101; Evidence={ECO:0000269|PubMed:7644496};
SimilarityBelongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitHomotetramer. {ECO:0000269|PubMed:7547867, ECO:0000269|PubMed:8031770}.
Web ResourceName=Wikipedia; Note=CXCL4 entry; URL="http://en.wikipedia.org/wiki/CXCL4";
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