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MGP002775

Record overview

MGPD IDMGP002775
Gene ID6348
SpeciesHomo sapiens (Human)
Gene Namechemokine (C-C motif) ligand 3
Gene Symbol CCL3
SynonymsMIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha;
Alternate namesC-C motif chemokine 3; G0/G1 switch regulatory protein 19-1; PAT 464.1; SIS-beta; macrophage inflammatory protein 1-alpha; small inducible cytokine A3 (homologous to mouse Mip-1a); tonsillar lymphocyte LD78 alpha protein;
Chromosome17
Map Location17q12
SummaryThis locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
OrthologsView orthologs and multiple alignments for CCL3

Proteins

C-C motif chemokine 3 precursor
Refseq ID:NP_002974
Protein GI:4506843
UniProt ID:P10147
mRNA ID:NM_002983
Length:92
RefSeq Status:
MQVSTAALAVLLCTMALCNQFSASLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPGVIFLTKRSRQVCADPSEEWVQKYVSDLELSA
 
sig_peptide: 1..23
calculated_mol_wt: 2387
peptide sequence: 
MQVSTAALAVLLCTMALCNQFSA

mat_peptide: 24..92
product: C-C motif chemokine 3
calculated_mol_wt: 7717
peptide sequence: 
SLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPGVIFLTKRSRQVCADPSEEWVQKYVSDLELSA

mat_peptide: 27..92
product: MIP-1 alpha(4-69)
exception: alternative processing
calculated_mol_wt: 7445
peptide sequence: 
ADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPGVIFLTKRSRQVCADPSEEWVQKYVSDLELSA
 
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