MGP Database

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MGP002775

Ontology/Pathway Information

Entrez Gene ID6348
Gene Namechemokine (C-C motif) ligand 3
Gene Symbol CCL3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0005576 IDA:BHF-UCLCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0005622 IDA:UniProtKBCintracellular
GO:0004698 IDA:UniProtKBFcalcium-dependent protein kinase C activity
GO:0031726 IPI:UniProtKBFCCR1 chemokine receptor binding
GO:0031730 IPI:UniProtKBFCCR5 chemokine receptor binding
GO:0042056 IDA:UniProtKBFchemoattractant activity
GO:0008009 IDA:UniProtKBFchemokine activity
GO:0042802 IPI:IntActFidentical protein binding
GO:0016301 IDA:UniProtKBFkinase activity
GO:0016004 IDA:UniProtKBFphospholipase activator activity
GO:0004672 IDA:UniProtKBFprotein kinase activity
GO:0043615 ISS:UniProtKBPastrocyte cell migration
GO:0007610 IDA:UniProtKBPbehavior
GO:0006816 IDA:UniProtKBPcalcium ion transport
GO:0019722 IDA:UniProtKBPcalcium-mediated signaling
GO:0001775 IDA:UniProtKBPcell activation
GO:0007267 IDA:UniProtKBPcell-cell signaling
GO:0006874 IDA:UniProtKBPcellular calcium ion homeostasis
GO:0071346 IEP:UniProtKBPcellular response to interferon-gamma
GO:0071347 IEP:UniProtKBPcellular response to interleukin-1
GO:0071407 IDA:UniProtKBPcellular response to organic cyclic compound
GO:0071356 IEP:UniProtKBPcellular response to tumor necrosis factor
GO:0006935 IDA:UniProtKBPchemotaxis
GO:0007010 IDA:UniProtKBPcytoskeleton organization
GO:0048245 IDA:UniProtKBPeosinophil chemotaxis
GO:0043308 IDA:UniProtKBPeosinophil degranulation
GO:0006887 IDA:UniProtKBPexocytosis
GO:0071621 IDA:UniProtKBPgranulocyte chemotaxis
GO:0006954 IDA:UniProtKBPinflammatory response
GO:0031663 IDA:UniProtKBPlipopolysaccharide-mediated signaling pathway
GO:0048247 IDA:UniProtKBPlymphocyte chemotaxis
GO:0048246 ISS:UniProtKBPmacrophage chemotaxis
GO:0000165 IMP:UniProtKBPMAPK cascade
GO:0002548 IDA:UniProtKBPmonocyte chemotaxis
GO:0043922 IDA:UniProtKBPnegative regulation by host of viral transcription
GO:0030502 IDA:UniProtKBPnegative regulation of bone mineralization
GO:0010629 IDA:UniProtKBPnegative regulation of gene expression
GO:0045671 IDA:UniProtKBPnegative regulation of osteoclast differentiation
GO:0030593 IDA:UniProtKBPneutrophil chemotaxis
GO:0001649 IEP:UniProtKBPosteoblast differentiation
GO:0050918 IDA:GOCPpositive chemotaxis
GO:0090280 TAS:BHF-UCLPpositive regulation of calcium ion import
GO:0051928 IDA:UniProtKBPpositive regulation of calcium ion transport
GO:0050850 IMP:UniProtKBPpositive regulation of calcium-mediated signaling
GO:0043085 IDA:GOCPpositive regulation of catalytic activity
GO:0030335 IDA:UniProtKBPpositive regulation of cell migration
GO:0070374 IDA:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0010628 IDA:UniProtKBPpositive regulation of gene expression
GO:0050729 ISS:UniProtKBPpositive regulation of inflammatory response
GO:0050718 ISS:UniProtKBPpositive regulation of interleukin-1 beta secretion
GO:2000503 IDA:UniProtKBPpositive regulation of natural killer cell chemotaxis
GO:0043525 ISS:UniProtKBPpositive regulation of neuron apoptotic process
GO:0051897 IEP:UniProtKBPpositive regulation of protein kinase B signaling
GO:0032760 ISS:UniProtKBPpositive regulation of tumor necrosis factor production
GO:0043491 IMP:UniProtKBPprotein kinase B signaling
GO:0006468 IDA:GOCPprotein phosphorylation
GO:0008360 IDA:UniProtKBPregulation of cell shape
GO:0051930 IDA:UniProtKBPregulation of sensory perception of pain
GO:0014808 IDA:UniProtKBPrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0070723 IDA:UniProtKBPresponse to cholesterol
GO:0009636 IDA:UniProtKBPresponse to toxic substance
GO:0023052 IEP:UniProtKBPsignaling
GO:0010818 IDA:UniProtKBPT cell chemotaxis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_15344Chemokine receptors bind chemokines
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_21340GPCR ligand binding
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14819Peptide ligand-binding receptors
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
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