MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002775

UniProt Annotations

Entry Information
Gene Namechemokine (C-C motif) ligand 3
Protein EntryCCL3_HUMAN
UniProt IDP10147
SpeciesHuman
Comments
Comment typeDescription
FunctionMonokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). {ECO:0000269|PubMed:8525373}.
InductionBy TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)).
InteractionSelf; NbExp=3; IntAct=EBI-8459634, EBI-8459634; P14735:IDE; NbExp=3; IntAct=EBI-8459634, EBI-2556886;
PtmN-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T- cells.
SimilarityBelongs to the intercrine beta (chemokine CC) family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitSelf-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69). {ECO:0000269|PubMed:12070155}.
Web ResourceName=Wikipedia; Note=Macrophage inflammatory protein entry; URL="http://en.wikipedia.org/wiki/Macrophage_Inflammatory_Protein";
  logo