MGP Database

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MGP002784

Ontology/Pathway Information

Entrez Gene ID6366
Gene Namechemokine (C-C motif) ligand 21
Gene Symbol CCL21
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IEA:UniProtKB-KWCextracellular space
GO:0031732 ISS:BHF-UCLFCCR7 chemokine receptor binding
GO:0008009 IDA:UniProtKBFchemokine activity
GO:0042379 IDA:UniProtKBFchemokine receptor binding
GO:0032862 IDA:BHF-UCLPactivation of Rho GTPase activity
GO:0007267 TAS:ProtIncPcell-cell signaling
GO:0060326 IDA:UniProtKBPcell chemotaxis
GO:0048469 ISS:BHF-UCLPcell maturation
GO:0002407 IDA:BHF-UCLPdendritic cell chemotaxis
GO:0097026 ISS:BHF-UCLPdendritic cell dendrite assembly
GO:0001768 IDA:BHF-UCLPestablishment of T cell polarity
GO:0007186 IDA:UniProtKBPG-protein coupled receptor signaling pathway
GO:0006955 TAS:ProtIncPimmune response
GO:0001771 ISS:BHF-UCLPimmunological synapse formation
GO:0006954 NAS:BHF-UCLPinflammatory response
GO:0035759 IDA:BHF-UCLPmesangial cell-matrix adhesion
GO:2000548 ISS:BHF-UCLPnegative regulation of dendritic cell dendrite assembly
GO:2000107 IDA:BHF-UCLPnegative regulation of leukocyte apoptotic process
GO:1903237 IDA:UniProtKBPnegative regulation of leukocyte tethering or rolling
GO:0030838 IDA:BHF-UCLPpositive regulation of actin filament polymerization
GO:0033630 IDA:BHF-UCLPpositive regulation of cell adhesion mediated by integrin
GO:0001954 IDA:UniProtKBPpositive regulation of cell-matrix adhesion
GO:2000147 IDA:BHF-UCLPpositive regulation of cell motility
GO:0050921 ISS:BHF-UCLPpositive regulation of chemotaxis
GO:0002606 ISS:BHF-UCLPpositive regulation of dendritic cell antigen processing and presentation
GO:0070374 IDA:BHF-UCLPpositive regulation of ERK1 and ERK2 cascade
GO:0051491 IDA:BHF-UCLPpositive regulation of filopodium assembly
GO:0010560 ISS:BHF-UCLPpositive regulation of glycoprotein biosynthetic process
GO:0043123 IDA:BHF-UCLPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046330 IDA:BHF-UCLPpositive regulation of JNK cascade
GO:2000529 IDA:BHF-UCLPpositive regulation of myeloid dendritic cell chemotaxis
GO:0090023 IDA:BHF-UCLPpositive regulation of neutrophil chemotaxis
GO:0043552 IDA:BHF-UCLPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0045860 IDA:BHF-UCLPpositive regulation of protein kinase activity
GO:0051897 IDA:BHF-UCLPpositive regulation of protein kinase B signaling
GO:0031274 IDA:BHF-UCLPpositive regulation of pseudopodium assembly
GO:0048260 ISS:BHF-UCLPpositive regulation of receptor-mediated endocytosis
GO:2000406 IDA:MGIPpositive regulation of T cell migration
GO:0051209 IDA:BHF-UCLPrelease of sequestered calcium ion into cytosol
GO:0034695 IDA:BHF-UCLPresponse to prostaglandin E
GO:0031529 IDA:BHF-UCLPruffle organization
GO:0031295 ISS:BHF-UCLPT cell costimulation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_15344Chemokine receptors bind chemokines
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_19231G alpha (i) signalling events
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14819Peptide ligand-binding receptors
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
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