MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002784

UniProt Annotations

Entry Information
Gene Namechemokine (C-C motif) ligand 21
Protein EntryCCL21_HUMAN
UniProt IDO00585
SpeciesHuman
Comments
Comment typeDescription
FunctionInhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
SimilarityBelongs to the intercrine beta (chemokine CC) family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitMonomer. Binds to CCR7. {ECO:0000269|PubMed:22221265}.
Tissue SpecificityHighly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen.
Web ResourceName=Wikipedia; Note=CCL21 entry; URL="http://en.wikipedia.org/wiki/CCL21";
  logo