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MGP003007

Record overview

MGPD IDMGP003007
Gene ID6778
SpeciesHomo sapiens (Human)
Gene Namesignal transducer and activator of transcription 6, interleukin-4 induced
Gene Symbol STAT6
SynonymsSTAT6B; STAT6C; D12S1644; IL-4-STAT;
Alternate namessignal transducer and activator of transcription 6; STAT, interleukin4-induced; transcription factor IL-4 STAT;
Chromosome12
Map Location12q13
SummaryThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
OrthologsView orthologs and multiple alignments for STAT6

Proteins

signal transducer and activator of transcription 6 isoform 1
Refseq ID:NP_003144
Protein GI:23397678
UniProt ID:P42226
mRNA ID:NM_003153
Length:847
RefSeq Status:
MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDTVQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFR
QILQGEKKAVMEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKR
IQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLR
FLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLP
IQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWS
QFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIR
SLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSI
PPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPPTEQ
DLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMDLRANPSW
 
signal transducer and activator of transcription 6 isoform 1
Refseq ID:NP_001171550
Protein GI:296010866
UniProt ID:P42226
mRNA ID:NM_001178079
Length:847
RefSeq Status:
Protein sequence is identical to GI:23397678 (mRNA isoform)
 
signal transducer and activator of transcription 6 isoform 1
Refseq ID:NP_001171549
Protein GI:296010864
UniProt ID:P42226
mRNA ID:NM_001178078
Length:847
RefSeq Status:
Protein sequence is identical to GI:23397678 (mRNA isoform)
 
signal transducer and activator of transcription 6 isoform 2
Refseq ID:NP_001171551
Protein GI:296010868
UniProt ID:P42226
mRNA ID:NM_001178080
Length:737
RefSeq Status:
MEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQL
AGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPL
VRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPL
VVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGR
GFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLA
QLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEE
SVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQ
GESGGGSLGAQPLLQPSHYGQSGISMSHMDLRANPSW
 
signal transducer and activator of transcription 6 isoform 2
Refseq ID:NP_001171552
Protein GI:296010870
UniProt ID:B4DQB3
mRNA ID:NM_001178081
Length:737
RefSeq Status:
Protein sequence is identical to GI:296010868 (mRNA isoform)
 
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