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MGP003007

UniProt Annotations

Entry Information
Gene Namesignal transducer and activator of transcription 6, interleukin-4 induced
Protein EntrySTAT6_HUMAN
UniProt IDP42226
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P42226-1; Sequence=Displayed; Name=2; IsoId=P42226-2; Sequence=VSP_031871, VSP_031872; Name=3; IsoId=P42226-3; Sequence=VSP_045282; Note=No experimental confirmation available.;
FunctionCarries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269|PubMed:17210636}.
InteractionSelf; NbExp=2; IntAct=EBI-1186478, EBI-1186478; Q09472:EP300; NbExp=2; IntAct=EBI-1186478, EBI-447295; P24394:IL4R; NbExp=4; IntAct=EBI-1186478, EBI-367009; Q9UHD2:TBK1; NbExp=7; IntAct=EBI-1186478, EBI-356402; Q86WV6:TMEM173; NbExp=12; IntAct=EBI-1186478, EBI-2800345;
PtmTyrosine phosphorylated following stimulation by IL4/interleukin-4 and IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling. {ECO:0000250, ECO:0000269|PubMed:17210636}.
SimilarityBelongs to the transcription factor STAT family. {ECO:0000305}.
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular LocationCytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
SubunitForms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif. {ECO:0000250, ECO:0000269|PubMed:12138096, ECO:0000269|PubMed:14757047}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/stat6/";
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