MGP Database

MGP003007

Ontology/Pathway Information

Entrez Gene ID	6778
Gene Name	signal transducer and activator of transcription 6, interleukin-4 induced
Gene Symbol	STAT6
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:HPA	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0045121	IEA:Ensembl	C	membrane raft
GO:0000790	IEA:Ensembl	C	nuclear chromatin
GO:0005654	IDA:HPA	C	nucleoplasm
GO:0005509	IEA:InterPro	F	calcium ion binding
GO:0042802	IPI:IntAct	F	identical protein binding
GO:0019903	IPI:UniProtKB	F	protein phosphatase binding
GO:0000979	IEA:Ensembl	F	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003700	TAS:ProtInc	F	sequence-specific DNA binding transcription factor activity
GO:0004871	IEA:InterPro	F	signal transducer activity
GO:0070301	IEA:Ensembl	P	cellular response to hydrogen peroxide
GO:1902170	IEA:Ensembl	P	cellular response to reactive nitrogen species
GO:0045087	TAS:Reactome	P	innate immune response
GO:0035771	IMP:UniProtKB	P	interleukin-4-mediated signaling pathway
GO:0033598	IEA:Ensembl	P	mammary gland epithelial cell proliferation
GO:0060443	IEA:Ensembl	P	mammary gland morphogenesis
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0002829	IEA:Ensembl	P	negative regulation of type 2 immune response
GO:0048295	IEA:Ensembl	P	positive regulation of isotype switching to IgE isotypes
GO:0045944	IEA:Ensembl	P	positive regulation of transcription from RNA polymerase II promoter
GO:0032481	TAS:Reactome	P	positive regulation of type I interferon production
GO:0042127	IEA:Ensembl	P	regulation of cell proliferation
GO:0006357	TAS:ProtInc	P	regulation of transcription from RNA polymerase II promoter
GO:0007165	TAS:ProtInc	P	signal transduction
GO:0002296	IEA:Ensembl	P	T-helper 1 cell lineage commitment
GO:0006351	IEA:UniProtKB-KW	P	transcription, DNA-templated

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_118823	Cytosolic sensors of pathogen-associated DNA
REACT_17025	Downstream signal transduction
REACT_6900	Immune System
REACT_6802	Innate Immune System
REACT_16888	Signaling by PDGF
REACT_111102	Signal Transduction
REACT_163734	STAT6-mediated induction of chemokines
REACT_147841	STING mediated induction of host immune responses